A-to-I RNA editing: The "ADAR" side of human cancer

被引：83

作者：

Galeano, Federica ^{[1
]}

Tomaselli, Sara ^{[1
]}

Locatelli, Franco ^{[1
,2
]}

Gallo, Angela ^{[1
]}

机构：

[1] IRCCS Osped Pediat Bambino Gesu, Oncohaematol Dept, RNA Editing Lab, I-00165 Rome, Italy

[2] Univ Pavia, I-27100 Pavia, Italy

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2012年 / 23卷 / 03期

关键词：

A-to-I RNA editing; ADAR enzymes; Human cancers; SARCOMA-ASSOCIATED HERPESVIRUS; PROSTATE-CANCER; HUMAN TRANSCRIPTOME; HUMAN GLIOBLASTOMA; BLADDER-CANCER; MESSENGER-RNA; BREAST-CANCER; EDITED RNAS; HUMAN BRAIN; GENE;

D O I：

10.1016/j.semcdb.2011.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human diseases, including tumours. A-to-I RNA editing changes the nucleotide sequence of target RNAs, introducing A-to-I/G "mutations". Since ADAR enzymes catalyse this nucleotide conversion, their expression/activity is essential and finely regulated in normal cells. This review summarizes the available knowledge on A-to-I RNA editing in the cancer field, giving a new view on how ADARs may play a role in carcinogenesis. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：244 / 250

页数：7

共 67 条

[1] Widespread A-to-I RNA editing of alu-containing mRNAs in the human transcriptome [J].

Athanasiadis, A ;

Rich, A ;

Maas, S .

PLOS BIOLOGY, 2004, 2 (12) :2144-2158

[2] RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia [J].

Beghini, A ;

Ripamonti, CB ;

Peterlongo, P ;

Roversi, G ;

Cairoli, R ;

Morra, E ;

Larizza, L .

HUMAN MOLECULAR GENETICS, 2000, 9 (15) :2297-2304

[3] Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus [J].

Bergles, DE ;

Roberts, JDB ;

Somogyi, P ;

Jahr, CE .

NATURE, 2000, 405 (6783) :187-191

[4] A survey of RNA editing in human brain [J].

Blow, M ;

Futreal, PA ;

Wooster, R ;

Stratton, MR .

GENOME RESEARCH, 2004, 14 (12) :2379-2387

[5] RNA editing of human microRNAs [J].

Blow, Matthew J. ;

Grocock, Russell J. ;

van Dongen, Stijn ;

Enright, Anton J. ;

Dicks, Ed ;

Futreal, P. Andrew ;

Wooster, Richard ;

Stratton, Michael R. .

GENOME BIOLOGY, 2006, 7 (04)

[6] Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia [J].

Castor, A ;

Nilsson, L ;

Åstrand-Grundström, I ;

Buitenhuis, M ;

Ramirez, C ;

Anderson, K ;

Strömbeck, B ;

Garwicz, S ;

Békássy, AN ;

Schmiegelow, K ;

Lausen, B ;

Hokland, P ;

Lehmann, S ;

Juliusson, G ;

Johansson, B ;

Jacobsen, SEW .

NATURE MEDICINE, 2005, 11 (06) :630-637

[7]

Cathomas Gieri, 2003, Herpes, V10, P72

[8] Down-regulation of RNA editing in pediatric astrocytomas - ADAR2 editing activity inhibits cell migration and proliferation [J].

Cenci, Caterina ;

Barzotti, Rita ;

Galeano, Federica ;

Corbelli, Sandro ;

Rota, Rossella ;

Massimi, Luca ;

Di Rocco, Concezio ;

O'Connell, Mary A. ;

Gallo, Angela .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (11) :7251-7260

[9] MicroRNAs modulate hematopoietic lineage differentiation [J].

Chen, CZ ;

Li, L ;

Lodish, HF ;

Bartel, DP .

SCIENCE, 2004, 303 (5654) :83-86

[10] Prostate cancer [J].

Damber, Jan-Erik ;

Aus, Gunnar .

LANCET, 2008, 371 (9625) :1710-1721

← 1 2 3 4 5 6 7 →