The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

被引：220
作者：
Mastaglio, Sara [1 ]
Ruggeri, Annalisa [1 ]
Risitano, Antonio M. [2 ]
Angelillo, Piera [1 ]
Yancopoulou, Despina [3 ]
Mastellos, Dimitrios C. [4 ]
Huber-Lang, Markus [5 ]
Piemontese, Simona [1 ]
Assanelli, Andrea [1 ]
Garlanda, Cecilia [6 ,7 ]
Lambris, John D. [8 ]
Ciceri, Fabio [1 ,9 ]
机构：
[1] IRCCS San Raffaele Sci Inst, Hematol & Bone Marrow Transplantat Unit, Milan, Italy
[2] Federico II Univ Naples, Dept Clin Med & Surg, Naples, Italy
[3] Amyndas Pharmaceut, Glifadha, Greece
[4] Natl Ctr Sci Res Demokritos, Athens, Greece
[5] Univ Hosp Ulm, Inst Expt Trauma Immunol, Ulm, Germany
[6] IRCCS Humanitas Clin & Res Ctr, Milan, Italy
[7] Humanitas Univ, Milan, Italy
[8] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA
[9] Univ Vita Salute San Raffaele, Milan, Italy
来源：
CLINICAL IMMUNOLOGY | 2020年 / 215卷
基金：
美国国家卫生研究院;
关键词：
COMPSTATIN; LUNG;
D O I：
10.1016/j.clim.2020.108450
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Acute respiratory distress syndrome (ARDS) is a devastating clinical manifestation of COVID-19 pneumonia and is mainly based on an immune-driven pathology. Mounting evidence suggests that COVID-19 is fueled by a maladaptive host inflammatory response that involves excessive activation of innate immune pathways. While a "cytokine storm" involving IL-6 and other cytokines has been documented, complement C3 activation has been implicated as an initial effector mechanism that exacerbates lung injury in preclinical models of SARS-CoV infection. C3-targeted intervention may provide broader therapeutic control of complement-mediated inflammatory damage in COVID-19 patients. Herein, we report the clinical course of a patient with severe ARDS due to COVID-19 pneumonia who was safely and successfully treated with the compstatin-based complement C3 inhibitor AMY-101.
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页数：4
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