Nanomaterial-based electrochemical sensors for the detection of neurochemicals in biological matrices

被引:86
作者
Azzouz, Abdelmonaim [1 ]
Goud, K. Yugender [2 ]
Raza, Nadeem [3 ]
Ballesteros, Evaristo [1 ]
Lee, Sung-Eun [4 ]
Hong, Jongki [5 ]
Deep, Akash [6 ]
Kim, Ki-Hyun [2 ]
机构
[1] Univ Jaen, Dept Phys & Analyt Chem, EPS Linares, E-23700 Jaen, Spain
[2] Hanyang Univ, Dept Civil & Environm Engn, 222 Wangsimni Ro, Seoul 04763, South Korea
[3] Bahauddin Zakariya Univ Multan, Govt Emerson Coll, Multan, Pakistan
[4] Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea
[5] Kyung Hee Univ, Coll Pharm, 26 Kyungheedae Ro, Seoul 02447, South Korea
[6] CSIO, CSIR, Nanosci & Nanotechnol Lab, Sect 30 C, Chandigarh 160030, India
基金
新加坡国家研究基金会;
关键词
Nanomaterials; Neurochemicals; Electrochemical sensors; Dopamine; Molecularly imprinted polymers; Metal organic frameworks; MOLECULARLY IMPRINTED POLYMERS; GLASSY-CARBON ELECTRODE; METAL-ORGANIC FRAMEWORK; BORON-DOPED DIAMOND; SELF-ASSEMBLED MONOLAYERS; PENCIL GRAPHITE ELECTRODE; ASCORBIC-ACID; GRAPHENE OXIDE; PASTE ELECTRODE; URIC-ACID;
D O I
10.1016/j.trac.2018.08.002
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Neurochemicals such as dopamine, glutamate, GABA, adenosine, and serotonin are efficient indicators for quantifying the dynamics of many brain disorders. Both in vivo and in vitro detection strategies for those neurochemicals are important in treating various human diseases. Along with common, conventional tools (e.g., microelectrodes, biosensors, spectrophotometry, Fourier transform infrared, Raman, chromatography, fluorescence, flow injection, and capillary electrophoresis), electrochemical sensors based on nanomaterials (NMs; e.g., graphene, carbon nanotubes, molecular imprinted polymers, metal organic frameworks, and metallic nanoparticles) have emerged as potent tools for the quantitation of neurochemicals due to their robust designs, selectivity, sensitivity, precision, and accuracy. The performance of the latter varies widely because of differences in their sensing efficiencies. This review provides a brief introduction to those electrochemical sensors with a detailed overview of the latest trends, limitations of NM-based sensing techniques, and the potential for their future expansion for various neurochemicals. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码:15 / 34
页数:20
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