Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

被引：108

作者：

Schuemann, Jan ^{[1
,2
]}

Bagley, Alexander F. ^{[3
]}

Berbeco, Ross ^{[2
,4
,31
]}

Bromma, Kyle ^{[5
]}

Butterworth, Karl T. ^{[6
]}

Byrne, Hilary L. ^{[7
]}

Chithrani, B. Devika ^{[5
]}

Cho, Sang Hyun ^{[8
,9
]}

Cook, Jason R. ^{[10
]}

Favaudon, Vincent ^{[11
]}

Gholami, Yaser H. ^{[7
]}

Gargioni, Elisabetta ^{[12
]}

Hainfeld, James F. ^{[13
]}

Hespeels, Felicien ^{[14
]}

Heuskin, Anne-Catherine ^{[14
]}

Ibeh, Udoka M. ^{[2
,4
,36
]}

Kuncic, Zdenka ^{[7
,15
]}

Kunjachan, Sijumon ^{[2
,4
]}

Lacombe, Sandrine ^{[16
,34
]}

Lucas, Stephane ^{[14
]}

Lux, Francois ^{[17
,18
,30
]}

McMahon, Stephen ^{[6
,35
]}

Nevozhay, Dmitry ^{[9
,19
]}

Ngwa, Wilfred ^{[2
,4
,36
]}

Payne, J. Donald ^{[20
]}

Penninckx, Sebastien ^{[14
]}

Porcel, Erika ^{[16
,34
]}

Prise, Kevin M. ^{[6
]}

Rabus, Hans ^{[21
,32
]}

Ridwan, Sharif M. ^{[22
]}

Rudek, Benedikt ^{[1
,2
,23
,33
]}

Sanche, Leon ^{[24
]}

Singh, Bijay ^{[25
]}

Smilowitz, Henry M. ^{[22
]}

Sokolov, Konstantin, V ^{[9
,19
,26
,27
]}

Sridhar, Srinivas ^{[25
]}

Stanishevskiy, Yaroslav ^{[13
]}

Sung, Wonmo ^{[1
,2
,33
]}

Tillement, Olivier ^{[17
,18
]}

Virani, Needa ^{[2
,4
]}

Yantasee, Wassana ^{[28
]}

Krishnan, Sunil ^{[29
]}

机构：

[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA

[2] Harvard Med Sch, Boston, MA 02114 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

[4] Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Radiat Oncol, 75 Francis St, Boston, MA 02115 USA

[5] Univ Victoria, Dept Phys & Astron, Victoria, BC, Canada

[6] Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland

[7] Univ Sydney, Inst Med Phys, Sch Phys, Fac Sci, Sydney, NSW, Australia

[8] Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA

[9] Univ Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77030 USA

[10] NanoHybrids Inc, Austin, TX 78744 USA

[11] Univ Paris Sud, Univ Paris Saclay, Inst Curie, INSERM,CNRS,U 1020,UMR 3347, F-91405 Orsay, France

[12] Univ Med Ctr Hamburg Eppendorf, Dept Radiotherapy & Radiat Oncol, D-20246 Hamburg, Germany

[13] Nanoporbes, Yaphank, NY USA

[14] Univ Namur, NAmur Res Inst LIfe Sci NARILIS, Lab Anal Nucl React, 61 Rue Bruxelles, B-5000 Namur, Belgium

[15] Univ Sydney, Nano Inst, Sydney, NSW, Australia

[16] Univ Paris Saclay, Inst Sci Mol Orsay, CNRS, F-91405 Orsay, France

[17] NH TherAguix SAS, Villeurbanne, France

[18] Univ Claude Bernard Lyon 1, CNRS, Univ Lyon, Inst Lumiere Mat, Lyon, France

[19] Far Eastern Fed Univ, Sch Biomed, Vladivostok 690950, Russia

[20] Aurorad Inc, Houston, TX 77054 USA

[21] Phys Tech Bundesanstalt PTB, D-10715 Berlin, Germany

[22] Univ Connecticut, Ctr Hlth, Farmington, CT USA

[23] Boston Univ, Boston, MA 02215 USA

[24] Univ Sherbrooke, Dept Nucl Med & Radiobiol, Sherbrooke, PQ, Canada

[25] Northeastern Univ, Dept Phys, Boston, MA 02115 USA

[26] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

[27] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

[28] Oregon Hlth & Sci Univ, Dept Biomed Engn, Portland, OR 97201 USA

[29] Mayo Clin Florida, Dept Radiat Oncol, Jacksonville, FL USA

[30] Inst Univ France IUF, Paris, France

[31] Brigham & Womens Hosp, Dana Farber Canc Inst, 75 Francis St, Boston, MA 02115 USA

[32] Phys Tech Bundesanstalt PTB, D-38116 Braunschweig, Germany

[33] Massachusetts Gen Hosp, Boston, MA 02114 USA

[34] Univ Paris Sud, Univ Paris Saclay, CNRS, ISMO,UMR 8625, F-91405 Orsay, France

[35] Queens Univ Belfast, 97 Lisburn Rd, Belfast BT9 7AE, Antrim, North Ireland

[36] Brigham & Womans Hosp, Boston, MA USA

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2020年 / 65卷 / 21期

关键词：

metal nanoparticles; nanoparticle imaging; modeling; therapeutic applications of nanoparticles; theranostics; radiotherapy; immunotherapy; IRON-OXIDE NANOPARTICLES; MONTE-CARLO-SIMULATION; COMPUTED-TOMOGRAPHY XFCT; RAY-FLUORESCENCE TOMOGRAPHY; SECONDARY-ELECTRON SPECTRA; VASCULAR DISRUPTING AGENTS; GOLD NANOPARTICLES; DOSE ENHANCEMENT; DNA-DAMAGE; IN-VIVO;

D O I：

10.1088/1361-6560/ab9159

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

引用

页数：63

共 296 条

[1] Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo [J].

Aaron, Jesse ;

Nitin, Nitin ;

Travis, Kort ;

Kumar, Sonia ;

Collier, Tom ;

Park, Sun Young ;

Jose-Yacaman, Miguel ;

Coghlan, Lezlee ;

Follen, Michele ;

Richards-Kortum, Rebecca ;

Sokolov, Konstantin .

JOURNAL OF BIOMEDICAL OPTICS, 2007, 12 (03)

[2] Dynamic Imaging of Molecular Assemblies in Live Cells Based on Nanoparticle Plasmon Resonance Coupling [J].

Aaron, Jesse ;

Travis, Kort ;

Harrison, Nathan ;

Sokolov, Konstantin .

NANO LETTERS, 2009, 9 (10) :3612-3618

[3]

Achterhold K, 2013, SCI REP-UK, V3, DOI [10.1038/srep01313, 10.1038/srep03209]

[4] Synchrotron Stereotactic Radiation Therapy: A Report on Phase 1/2 Clinical Trial Achievements, Ongoing Developments, and Long-Term Prospects [J].

Adam, J. F. ;

Balosso, J. ;

Renier, M. ;

Elleaume, H. ;

Esteve, F. ;

Berkvens, P. ;

Nemoz, C. ;

Brochard, T. ;

Tessier, A. ;

Verry, C. ;

Le Bas, J. F. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 96 (02) :E624-E625

[5] Order of Magnitude Sensitivity Increase in X-ray Fluorescence Computed Tomography (XFCT) Imaging With an Optimized Spectro-Spatial Detector Configuration: Theory and Simulation [J].

Ahmad, Moiz ;

Bazalova, Magdalena ;

Xiang, Liangzhong ;

Xing, Lei .

IEEE TRANSACTIONS ON MEDICAL IMAGING, 2014, 33 (05) :1119-1128

[6] Advanced Gold Nanomaterials for Photothermal Therapy of Cancer [J].

Ahmad, Rasheed ;

Fu, Juan ;

He, Nongyue ;

Li, Song .

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2016, 16 (01) :67-80

[7] Enhancement of radiation effects by bismuth oxide nanoparticles for kilovoltage x-ray beams: A dosimetric study using a novel multi-compartment 3D radiochromic dosimeter [J].

Alqathami, M. ;

Blencowe, A. ;

Yeo, U. J. ;

Franich, R. ;

Doran, S. ;

Qiao, G. ;

Geso, M. .

7TH INTERNATIONAL CONFERENCE ON 3D RADIATION DOSIMETRY (IC3DDOSE), 2013, 444

[8] Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer [J].

Antonia, S. J. ;

Villegas, A. ;

Daniel, D. ;

Vicente, D. ;

Murakami, S. ;

Hui, R. ;

Yokoi, T. ;

Chiappori, A. ;

Lee, K. H. ;

de Wit, M. ;

Cho, B. C. ;

Bourhaba, M. ;

Quantin, X. ;

Tokito, T. ;

Mekhail, T. ;

Planchard, D. ;

Kim, Y. -C. ;

Karapetis, C. S. ;

Hiret, S. ;

Ostoros, G. ;

Kubota, K. ;

Gray, J. E. ;

Paz-Ares, L. ;

de Castro Carpeno, J. ;

Wadsworth, C. ;

Melillo, G. ;

Jiang, H. ;

Huang, Y. ;

Dennis, P. A. ;

Ozguroglu, M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (20) :1919-1929

[9] Electron-induced damage of DNA and its components: Experiments and theoretical models [J].

Baccarelli, Isabella ;

Bald, Ilko ;

Gianturco, Franco A. ;

Illenberger, Eugen ;

Kopyra, Janina .

PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 2011, 508 (1-2) :1-44

[10] In Vivo Imaging and Quantification of Carbonic Anhydrase IX Expression as an Endogenous Biomarker of Tumor Hypoxia [J].

Bao, Bagna ;

Groves, Kevin ;

Zhang, Jun ;

Handy, Emma ;

Kennedy, Paul ;

Cuneo, Garry ;

Supuran, Claudiu T. ;

Yared, Wael ;

Rajopadhye, Milind ;

Peterson, Jeffrey D. .

PLOS ONE, 2012, 7 (11)

← 1 2 3 4 5 6 7 8 9 10 →