A Quinoline Antibiotic from Rhodococcus erythropolis JCM 6824

被引：57

作者：

Kitagawa, Wataru ^{[1
]}

Tamura, Tomohiro ^{[1
,2
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Res Inst Genome Based Biofactory, Toyohira Ku, Sapporo, Hokkaido 0628517, Japan

[2] Hokkaido Univ, Grad Sch Agr, Lab Mol Environm Microbiol, Kita Ku, Sapporo, Hokkaido 0608589, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 11期

关键词：

Actinobacteria; antibiotic; aurachin; quinoline; Rhodococcus;

D O I：

10.1038/ja.2008.96

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new quinoline antibiotic, aurachin RE, was isolated and identified from a culture broth of Rhodococcus erythropolis JCM 6824. The aurachin RE structure was determined based on NMR and mass spectrometric analysis. The structure is similar to that of aurachin C antibiotics that have been identified from Stigmatella aurantiaca. Compared to aurachin C, however, aurachin RE exhibits a wide and strong antimicrobial spectrum against both high- and low-GC Gram-positive bacteria.

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页码：680 / 682

页数：3

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