A balance of interleukin-12 and-23 in cancer

被引：100
作者：
Ngiow, Shin Foong [1 ]
Teng, Michele W. L. [2 ,3 ]
Smyth, Mark J. [1 ,3 ]
机构：
[1] Queensland Inst Med Res, Immunol Canc & Infect Lab, Herston, Qld 4006, Australia
[2] Queensland Inst Med Res, Canc Innmunoregulat & Imnnunotherapy Lab, Herston, Qld 4006, Australia
[3] Univ Queensland, Sch Med, Herston, Qld 4006, Australia
来源：
TRENDS IN IMMUNOLOGY | 2013年 / 34卷 / 11期
基金：
英国医学研究理事会;
关键词：
POTENT ANTITUMOR IMMUNITY; SQUAMOUS-CELL CARCINOMA; IFN-GAMMA; CLINICAL-SIGNIFICANCE; TUMOR SURVEILLANCE; DENDRITIC CELLS; IL-23; RECEPTOR; OCCULT CANCER; IL-12; EXPRESSION;
D O I：
10.1016/j.it.2013.07.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin (IL)-12 and IL-23 share the IL-12p40 molecule. IL-12 promotes T helper (Th)1 immunity and IL-23 promotes Th17 immunity, and it has recently become apparent that the balance between IL-12 and IL-23 is important in carcinogenesis. A series of studies demonstrated that, where tumor initiation, growth, and metastasis are concerned, IL-12 may act independently of interferon (IFN)-gamma, and IL-23 independently of IL-17A. This review explores the activity of IL-23 in carcinogenesis. In the context of the tumor-inhibitory effects of IL-12, and tumor-promoting effects of IL-23, we discuss the use of anti-IL-12p/23 monoclonal antibodies (mAbs) in autoimmune inflammatory disorders and the alternative specific neutralization of IL-23.
引用
收藏
页码：548 / 555
页数：8
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