Hyperandrogenism in a postmenopausal woman presenting with a metastatic ileum endocrine tumor

被引:8
作者
Bachelot, A
Meduri, G
Baudin, E
Kuttenn, F
Touraine, P
机构
[1] Hop Necker Enfants Malad, Dept Endocrinol & Reprod Med, F-75743 Paris 15, France
[2] Hop Bicetre, INSERM, U135, Unite Rech, Le Kremlin Bicetre, France
[3] Inst Gustave Roussy, Dept Nucl Med & Endocrine Oncol, Villejuif, France
关键词
ovarian tumor; hyperandrogenism; endocrine tumor; postmenopause;
D O I
10.1016/j.fertnstert.2003.07.040
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To elucidate the mechanism of the hyperandrogenism, found in a postmenopausal woman presenting an ileum endocrine tumor with ovarian metastases. Design: Case report. Setting: University hospital. Patient(s): A postmenopausal woman was referred for hirsutism. Basal plasma testosterone was high, 6.6 nM/L (normal, less than or equal to 0.7 nM/L). Pelvic magnetic resonance imaging revealed a 6-cm left ovarian mass. Intervention(s): Bilateral salpingo-oophorectomy was performed. Pathological examination found a bilateral metastatic endocrine ovarian tumor, associated with a functional stroma. A primary ileum endocrine tumor was discovered and resected. Main Outcome Measure(s): Immunohistochemical study of the expression of steroidogenic enzymes and and alpha subunits of hCG. Result(s): Immunohistochemical expression of steroidogenic enzymes was found in the ovarian stromal tissue surrounding the tumor but not in the metastatic tumoral cells. A substantial percentage of the metastatic tumoral cells was immunopositive for the beta and alpha subunit of hCG but not the ileal cells. Conclusion(s): These data suggest an hCG paracrine effect of the ovarian metastases tumor on the adjacent interstitial cells, resulting in the virilization of the patient.
引用
收藏
页码:675 / 678
页数:4
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