Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

被引：13
|
作者：
Hilchie, Ashley L. [1 ]
Wuerth, Kelli [1 ]
Hancock, Robert E. W. [1 ]
机构：
[1] Univ British Columbia, Ctr Microbial Dis & Immun Res, Vancouver, BC V5Z 1M9, Canada
来源：
NATURE CHEMICAL BIOLOGY | 2013年 / 9卷 / 12期
关键词：
PLASMACYTOID DENDRITIC CELLS; HUMAN MAST-CELLS; REGULATOR PEPTIDE; CATHELICIDIN LL-37; INNATE; RESPONSES; MACROPHAGES; LYMPHOCYTES; PROTECTION; IDR-1002;
D O I：
10.1038/NCHEMBIO.1393
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models. These biological properties suggest that host defense peptides, and synthetic derivatives thereof, possess clinical potential beyond the treatment of antibiotic-resistant infections. In this Review, we provide an overview of the biological activities of host defense and synthetic peptides, their mechanism(s) of action and new therapeutic applications and challenges that are associated with their clinical use.
引用
收藏
页码：761 / 768
页数：8
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