Cytotoxic 9,11-secosteroids from the South China Sea gorgonian Subergorgia suberosa

被引：19

作者：

Zhang, Gang ^{[1
,3
]}

Tang, Xuli ^{[2
]}

Cheng, Canling ^{[1
]}

Gong, Kaikai ^{[1
]}

Zhang, Xingwang ^{[1
]}

Zhu, Hongyan ^{[1
]}

Wu, Rongcui ^{[1
]}

Li, Pinglin ^{[1
]}

Li, Guoqiang ^{[1
]}

机构：

[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China

[2] Ocean Univ China, Coll Chem & Chem Engn, Qingdao 266100, Peoples R China

[3] Xiamen Med Coll, Xiamen Key Lab Biotechnol Chinese Tradit Med, Xiamen 361008, Peoples R China

来源：

STEROIDS | 2013年 / 78卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Gorgonian; Subergorgia suberosa; 9,11-Secosteroids; Structural identification; Cytotoxicity; STEROIDS; SECOSTEROIDS; BIOSYNTHESIS;

D O I：

10.1016/j.steroids.2013.05.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ten new 9,11-secosteroids, subergorgols A-J (1-10), including two pairs of epimers (3/4, and 6/7), along with three known analogues (11-13) were isolated from the South China Sea gorgonian Subergorgia suberosa. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses and comparison with the literature data. The cytotoxicities in vitro against three selected human tumor cell lines for all the compounds were evaluated. Compound 9 showed significant cytotoxicities toward both K562 and MDA-MB-231 cell lines with IC50 values of 5.5 and 6.2 mu M, respectively, and compound 10 also showed inhibitory activity against K562 cell line with an IC50 value of 6.5 mu M. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：845 / 850

页数：6

共 29 条

[1] 5 NEW POLAR STEROLS FROM THE BLACK CORAL ANTIPATHES-SUBPINNATA [J].

AIELLO, A ;

FATTORUSSO, E ;

MENNA, M .

STEROIDS, 1991, 56 (10) :513-517

[2] New 9,11-secosterols from gorgonia Subergorgia suberosa of the Indian Ocean [J].

Aknin, M ;

Costantino, V ;

Mangoni, A ;

Fattorusso, E ;

Gaydou, EM .

STEROIDS, 1998, 63 (11) :575-578

[3]

ALLEY MC, 1988, CANCER RES, V48, P589

[4]

Anjaneyulu ASR, 1997, INDIAN J CHEM B, V36, P418

[5]

Brown GD, 1998, NAT PROD REP, V15, P653

[6] Hirsutosterols A-G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta [J].

Chen, Bo-Wei ;

Chang, Shu-Ming ;

Huang, Chiung-Yao ;

Su, Jui-Hsin ;

Wen, Zhi-Hong ;

Wu, Yang-Chang ;

Sheu, Jyh-Horng .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (09) :3272-3278

[7] Three New 9,11-Secosterols from the Formosan Soft Coral Sinularia leptoclados [J].

Cheng, Shi-Yie ;

Chen, Hwa-Pyng ;

Wang, Shang-Kwei ;

Duh, Chang-Yih .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2011, 84 (06) :648-652

[8]

Chung IM, 2006, B KOREAN CHEM SOC, V27, P93

[9] Isolation and structure elucidation of new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa [J].

Garrido, L ;

Zubía, E ;

Ortega, MJ ;

Salvá, J .

STEROIDS, 2000, 65 (02) :85-88

[10] BIOSYNTHESIS OF MARINE STEROL SIDE-CHAINS [J].

GINER, JL .

CHEMICAL REVIEWS, 1993, 93 (05) :1735-1752

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