Perioperative therapies in surgical non N2 non-small cell lung cancer

被引：1

作者：

Ruppert, Anne-Marie ^{[1
,2
]}

Lavole, Armelle ^{[1
,2
]}

Assouad, Jalal ^{[3
]}

Cadranel, Jacques ^{[1
,2
]}

Wislez, Marie ^{[1
,2
]}

机构：

[1] Hop Tenon, AP HP, Serv Pneumol, F-75970 Paris, France

[2] Univ Paris 06, Sorbonne Univ, GRC 04, F-75252 Paris, France

[3] Hop Tenon, AP HP, Serv Chirurg Thorac, F-75970 Paris, France

来源：

BULLETIN DU CANCER | 2017年 / 104卷 / 01期

关键词：

Non small cell lung cancer; Chemotherapy; Adjuvant chemotherapy; Neo-adjuvant chemotherapy; Radiotherapy; VINORELBINE PLUS CISPLATIN; ADJUVANT CHEMOTHERAPY; PREOPERATIVE CHEMOTHERAPY; RANDOMIZED-TRIAL; DOUBLE-BLIND; DNA-REPAIR; STAGE-II; TUMOR; ADENOCARCINOMA; CLASSIFICATION;

D O I：

10.1016/j.bulcan.2016.10.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Platinum-based perioperative chemotherapy is actually the standard of care in stage II-IIIa non-small cell lung cancer (NSCLC). A benefit may also be seen in stage IB NSCLC with tumors of more than 4 cm of diameter. Perioperative chemotherapy improves 5-year survival of 4 to 15%. This benefit is mainly proved by postoperative chemotherapy trials. Nevertheless, preoperative chemotherapy has advantages: a better tolerance, an estimation of tumor chemosensibility, without an increased postoperative morbimortality. However, pTNM and pathological tumor analyses are modified. Indications of postoperative radiotherapy are limited. In early stage NSCLC (stage I-II), radiotherapy worsens survival. Radiotherapy is routinely achieved in NSCLC with parietal tumor invasion and incomplete tumor resection. Indications of immunotherapy and targeted therapies in case of oncogenic addiction remain to be established in resected NSCLC. Several biomarkers are studied to better describe the indications of perioperative chemotherapy: recognize groups of patients with a worse prognosis and distinguish chemosensibility of the tumor.

引用

页码：79 / 85

页数：7

共 46 条

[1] Parenteral anticoagulation in ambulatory patients with cancer [J].

Akl, Elie A. ;

Kahale, Lara A. ;

Ballout, Rami A. ;

Barba, Maddalena ;

Yosuico, Victor E. D. ;

van Doormaal, Frederiek F. ;

Middeldorp, Saskia ;

Bryant, Andrew ;

Schuenemann, Holger .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2014, (12)

[2]

[Anonymous], EUR J SURG ONCOL

[3] Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data [J].

Auperin, A. ;

Le Chevalier, T. ;

Le Pechoux, C. ;

Pignon, J. P. ;

Tribodet, H. ;

Burdett, S. ;

Stewart, L. A. ;

Tierney, J. F. ;

Stephens, R. J. ;

Arriagada, R. ;

Higgins, J. P. ;

Johnson, D. H. ;

van Meerbeeck, J. ;

Parmar, M. K. B. ;

Souhami, R. L. ;

Bergman, B. ;

Dautzenberg, B. ;

Douillard, J. Y. ;

Dunant, A. ;

Endo, C. ;

Girling, D. J. ;

Imaizumi, M. ;

Kato, H. ;

Keller, S. M. ;

Kimura, H. ;

Knuuttila, A. ;

Kodama, K. ;

Komaki, R. ;

Kris, M. G. ;

Lad, T. ;

Mineo, T. ;

Park, J. H. ;

Piantadosi, S. ;

Pyrhonen, S. ;

Rosell, R. ;

Scagliotti, G. V. ;

Seymour, L. W. ;

Shepherd, F. A. ;

Spiro, S. G. ;

Strauss, G. M. ;

Sylvester, R. ;

Tada, H. ;

Tanaka, F. ;

Torri, V. ;

Wada, H. ;

Waller, D. ;

Xu, G. C. .

LANCET, 2010, 375 (9722) :1267-1277

[4] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

[5] Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer [J].

Brahmer, Julie ;

Reckamp, Karen L. ;

Baas, Paul ;

Crino, Lucio ;

Eberhardt, Wilfried E. E. ;

Poddubskaya, Elena ;

Antonia, Scott ;

Pluzanski, Adam ;

Vokes, Everett E. ;

Holgado, Esther ;

Waterhouse, David ;

Ready, Neal ;

Gainor, Justin ;

Aren Frontera, Osvaldo ;

Havel, Libor ;

Steins, Martin ;

Garassino, Marina C. ;

Aerts, Joachim G. ;

Domine, Manuel ;

Paz-Ares, Luis ;

Reck, Martin ;

Baudelet, Christine ;

Harbison, Christopher T. ;

Lestini, Brian ;

Spigel, David R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (02) :123-135

[6] Prognostic Effect of Tumor Lymphocytic Infiltration in Resectable Non-Small-Cell Lung Cancer [J].

Brambilla, Elisabeth ;

Le Teuff, Gwenael ;

Marguet, Sophie ;

Lantuejoul, Sylvie ;

Dunant, Ariane ;

Graziano, Stephen ;

Pirker, Robert ;

Douillard, Jean-Yves ;

Le Chevalier, Thierry ;

Filipits, Martin ;

Rosell, Rafael ;

Kratzke, Robert ;

Popper, Helmut ;

Soria, Jean-Charles ;

Shepherd, Frances A. ;

Seymour, Lesley ;

Tsao, Ming Sound .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (11) :1223-+

[7]

Burdett S, 1998, LANCET, V352, P257

[8] Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data [J].

Burdett, Sarah ;

Rydzewska, Larysa H. M. ;

Tierney, Jayne F. ;

Auperin, Anne ;

Le Pechoux, Cecile ;

Le Chevalier, Thierry ;

Pignon, Jean-Pierre .

LANCET, 2014, 383 (9928) :1561-1571

[9] Adjuvant Chemotherapy for Non-Small-Cell Lung Cancer in the Elderly: A Population-Based Study in Ontario, Canada [J].

Cuffe, Sinead ;

Booth, Christopher M. ;

Peng, Yingwei ;

Darling, Gail E. ;

Li, Gavin ;

Kong, Weidong ;

Mackillop, William J. ;

Shepherd, Frances A. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15) :1813-1821

[10] Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial [J].

DeMatteo, Ronald P. ;

Ballman, Karla V. ;

Antonescu, Cristina R. ;

Maki, Robert G. ;

Pisters, Peter W. T. ;

Demetri, George D. ;

Blackstein, Martin E. ;

Blanke, Charles D. ;

von Mehren, Margaret ;

Brennan, Murray F. ;

Patel, Shreyaskumar ;

McCarter, Martin D. ;

Polikoff, Jonathan A. ;

Tan, Benjamin R. ;

Owzar, Kouros .

LANCET, 2009, 373 (9669) :1097-1104

← 1 2 3 4 5 →