Effect of an acidic beverage (Coca-Cola) on the pharmacokinetics of carbamazepine in healthy volunteers

The effect of an acidic beverage (Coca-Cola) on the pharmacokinetics of a single dose of carbamazepine was studied. In a two-way cross-over design with a 1 week washout period. 10 healthy volunteers were randomized to receive 200 mg carbamazepine orally with 300 ml of Coca-Cola or water. Blood samples were collected at Q 0.5, 1, 2, 3, 6, 9, 12, 24, 48 and 72 It after drug administration. Plasma carbamazepine levels were higher with Coca-Cola is compared to water The AUC(0-) and C-max of carbamazepine were significantly enhanced after Coca-Cola while was achieved earlier with Coca-Cola. The results of the study indicate that concomitant administration of Coca-Cola enhances the rate and extent of absorption of carbamazepine. (C) 2002 Prous Science. All rights reserved.