Listeria monocytogenes endocarditis: case report, review of the literature, and laboratory evaluation of potential novel antibiotic synergies

被引:24
作者
Kumaraswamy, Monika [1 ,2 ]
Do, Carter [3 ]
Sakoulas, George [3 ]
Nonejuie, Poochit [4 ]
Tseng, GuanWoei [5 ]
King, Helen [1 ]
Fierer, Joshua [1 ,2 ]
Pogliano, Joe [4 ]
Nizet, Victor [3 ,6 ]
机构
[1] Univ Calif San Diego, Div Infect Dis, 9500 Gilman Dr,Mail Code 0711, La Jolla, CA 92093 USA
[2] VA San Diego Healthcare Syst, Infect Dis Sect, San Diego, CA 92161 USA
[3] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA
[5] China Med Univ, Sch Med, Taichung 40402, Taiwan
[6] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
基金
美国国家卫生研究院;
关键词
Listeria monocytogenes; Endocarditis; Literature review; Treatment; Antibiotic synergy; ENTEROCOCCUS-FAECIUM; BETA-LACTAMS; AMPICILLIN; BINDING; MANAGEMENT; DAPTOMYCIN;
D O I
10.1016/j.ijantimicag.2017.12.032
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Endocarditis is a rare but serious manifestation of Listeria monocytogenes (LM). However, the optimal treatment strategy for LM endocarditis has yet to be established. Current antibiotic strategies for listeriosis include penicillin G or ampicillin (AMP) monotherapy, or AMP + gentamicin combination therapy which is often favored for endocarditis. The primary objective of our investigation was to assess the utility of AMP + ceftriaxone (CRO) and AMP + daptomycin (DAP) against LM, modeling less nephrotoxic antibiotic combinations traditionally used to manage resistant enterococcal endocarditis. Here we report a case of LM endocarditis, review the world literature, and evaluate alternative treatment strategies for listeriosis utilizing in vitro and ex vivo studies. The combination of AMP + CRO and AMP + DAP were each noted to have synergistic activity against a LM endocarditis isolate. Additionally, co-incubation of the isolate with sub-lethal concentrations of antibiotics (AMP, CRO, DAP, AMP + CRO or AMP + DAP) sensitized the bacterium to whole blood killing while pretreatment with CRO and DAP (at 1/4 MIC) sensitized the bacterium to neutrophil killing. However, these effects did not reflect potentiation of antibiotic activity to human cathelicidin peptide LL-37, which is abundant in neutrophils and highly active against LM. Interestingly, AMP pretreatment of the LM endocarditis isolate resulted in increased DAP binding to the bacterium when assessed by fluorescence microscopy. These in vitro and ex vivo studies suggest further investigation of combination therapy using AMP + CRO or AMP + DAP as an alternative treatment for LM infection is warranted. (C) 2018 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
引用
收藏
页码:468 / 478
页数:11
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