HIV and thyroid dysfunction

被引:31
作者
Parsa, Alan A. [1 ]
Bhangoo, Amrit [2 ]
机构
[1] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
[2] Miller Childrens Hosp, Long Beach, CA USA
关键词
HIV; Hypothyroidism; Hyperthyroidism; Graves' disease; Subclinical thyroid dysfunction; AIDS; IMMUNODEFICIENCY-VIRUS-INFECTION; ACTIVE ANTIRETROVIRAL THERAPY; SUBCLINICAL HYPOTHYROIDISM; IMMUNE RECONSTITUTION; GRAVES-DISEASE; INCREASED PREVALENCE; UNITED-STATES; WEIGHT-LOSS; ENDOCRINE; CHILDREN;
D O I
10.1007/s11154-013-9248-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Human Immunodeficiency virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS) are associated with dysfunction of many endocrine organs and their axis. HIV infectivity leads to altered metabolism, poor oral intake and increased prevalence of weight loss and wasting which may have a role in thyroid dysfunction. Overt thyroid dysfunction occurs at similar rates as the general population while subclinical disease such as nonthyroidal illness (sick euthyroid syndrome), subclinical hypothyroidism and isolated low T4 levels are more frequent. Moreover, HAART therapy can complicate thyroid function further through drug interactions and the immune reconstitution inflammatory syndrome (IRIS). In this review we report the common thyroid dysfunctions associated with HIV before and after HAART therapy. We discuss presentation, diagnostic work up, treatment and follow up in each condition.
引用
收藏
页码:127 / 131
页数:5
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