Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives

被引：1
|
作者：
Skrastina, I. [1 ]
Baran, A. [1 ]
Muceniece, D. [1 ]
机构：
[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 04期
关键词：
2-alkyl-5-arylimino-2,5-dihydroisothiazoles; 2-substituted N-arylamides of 2-alkylaminobut-2-enethioic acid; enamine-imine tautomerism; oxidative cyclization; UBER ISOTHIAZOLE; BENZOTHIAZOLES; CYTOTOXICITY; CYCLIZATION;
D O I：
10.1007/s10593-013-1290-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cyclization of 2-substituted N-arylamides of 3-alkylaminobut-2-enethioic acid gave a series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives containing a benzoyl or ester group at position 4. A study was carried out on the course of this reaction in the presence of various oxidizing agents, including halogens, N-bromosuccinimide, hydrogen peroxide. Some of the isothiazoles obtained in this work exhibited cytotoxic activity against both normal and cancer cell lines.
引用
收藏
页码：624 / 635
页数：12
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