Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives

被引：1

作者：

Skrastina, I. ^{[1
]}

Baran, A. ^{[1
]}

Muceniece, D. ^{[1
]}

机构：

[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 04期

关键词：

2-alkyl-5-arylimino-2,5-dihydroisothiazoles; 2-substituted N-arylamides of 2-alkylaminobut-2-enethioic acid; enamine-imine tautomerism; oxidative cyclization; UBER ISOTHIAZOLE; BENZOTHIAZOLES; CYTOTOXICITY; CYCLIZATION;

D O I：

10.1007/s10593-013-1290-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclization of 2-substituted N-arylamides of 3-alkylaminobut-2-enethioic acid gave a series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives containing a benzoyl or ester group at position 4. A study was carried out on the course of this reaction in the presence of various oxidizing agents, including halogens, N-bromosuccinimide, hydrogen peroxide. Some of the isothiazoles obtained in this work exhibited cytotoxic activity against both normal and cancer cell lines.

引用

页码：624 / 635

页数：12

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