Molecular oncology: current trends in diagnostics

被引：3

作者：

Lefferts, Joel A. ^{[1
]}

Bartels, Claudine L. ^{[1
]}

Tsongalis, Gregory J. ^{[1
]}

机构：

[1] Dartmouth Hitchcock Med Ctr, Dept Pathol, Dartmouth Med Sch, Lebanon, NH 03756 USA

来源：

FUTURE ONCOLOGY | 2008年 / 4卷 / 01期

关键词：

BCR-ABL; breast cancer; chronic myelogenous leukemia; real-time PCR; sentinel lymph node;

D O I：

10.2217/14796694.4.1.61

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Applications of molecular diagnostics to oncology have been slow to make their way to the clinical laboratory. While numerous genes and mutation spectra have been found to be involved in tumorigenesis, it is only recently that these findings begin to become useful in a clinical setting. Building on the technical knowledge obtained from molecular infectious disease testing, new instruments and assays have been developed to answer similar questions regarding qualitative, quantitative and genotyping issues. In this manuscript we describe two current examples of clinical molecular diagnostic applications, the assessment of BCR-ABL in chronic myelogenous leukemia patients and the detection of tumor cells in the sentinel lymph nodes of breast cancer patients, to demonstrate the role of molecular techniques in a routine clinical setting.

引用

页码：61 / 70

页数：10

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