Sonication-assisted drug encapsulation in layer-by-layer self-assembled gelatin-poly (styrenesulfonate) polyelectrolyte nanocapsules: process optimization

被引：8

作者：

Pandey, Abhijeet P. ^{[1
]}

Singh, Saurabh S. ^{[1
]}

Patil, Ganesh B. ^{[1
]}

Patil, Pravin O. ^{[1
]}

Bhavsar, Chetan J. ^{[1
]}

Deshmukh, Prashant K. ^{[1
]}

机构：

[1] HR Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut, Shirpur 425405, Maharashtra, India

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2015年 / 43卷 / 06期

关键词：

Design of experiments; Lornoxicam; nanocrystals; probe sonication; THIN-FILMS; OIL-CORE; DELIVERY; NANOPARTICLES; LORNOXICAM; ADSORPTION; RELEASE; SYSTEMS;

D O I：

10.3109/21691401.2014.898646

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report the development of Layer-by-Layer (LbL) polyelectrolyte self-assembled nanocrystalline drug-delivery platform using two experimental factors, namely the number of coatings and temperature during deposition with three varying levels. The optimized formulation (Fopt) was assessed for zeta potential and particle size using Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM). Charge reversal along with an increase in particle size confirmed coating of polyelectrolyte on drug nanocrystals. The FT-IR study revealed no signs of incompatibility or change in formulation property during preformulation and stability study. This fact was further supported by DSC results.

引用

页码：413 / 424

页数：12

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