Mouse Models in Bone Marrow Transplantation and Adoptive Cellular Therapy

被引：12

作者：

Arber, Caroline ^{[1
,2
]}

Brenner, Malcolm K. ^{[1
,2
]}

Reddy, Pavan ^{[3
]}

机构：

[1] Baylor Coll Med, Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Houston, TX 77030 USA

[3] Univ Michigan, Dept Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

SEMINARS IN HEMATOLOGY | 2013年 / 50卷 / 02期

关键词：

VERSUS-HOST-DISEASE; COLONY-STIMULATING FACTOR; UMBILICAL-CORD BLOOD; MINOR HISTOCOMPATIBILITY BARRIERS; RESTRICTED ANTIGEN RECEPTOR; HIGH-DOSE CYCLOPHOSPHAMIDE; DIFFERENT LY ANTIGENS; NATURAL-KILLER-CELLS; T-CELLS; ACUTE GRAFT;

D O I：

10.1053/j.seminhematol.2013.03.026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mouse models of transplantation have been indispensable to the development of bone marrow transplantation (BMT). Their role in the generation of basic science knowledge is invaluable and is subject to discussion below. However, this article focuses on the direct role and relevance of mouse models towards the clinical development and advances in BMT and adoptive T-cell therapy for human diseases. The authors aim to present a thoughtful perspective on the pros and cons of mouse models while noting that despite imperfections these models are obligatory for the development of science-based medicine. Semin Hematol 50:131-144. (C) 2013 Published by Elsevier Inc.

引用

页码：131 / 144

页数：14

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