Epidermal Growth Factor Receptor-Containing Exosomes Induce Tumor-Specific Regulatory T Cells

被引：167

作者：

Huang, Shao-hong ^{[1
]}

Li, Yun ^{[1
]}

Zhang, Jian ^{[1
]}

Rong, Jian ^{[2
]}

Ye, Sheng ^{[3
]}

机构：

[1] Third Affiliated Hosp, Dept Cardiothorac Surg, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Dept Anesthesiol, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Dept Med Oncol, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China

来源：

CANCER INVESTIGATION | 2013年 / 31卷 / 05期

关键词：

Lung cancer; Epidermal growth factor receptor; Tumor tolerance; Dendritic cell; Regulatory T cell; DENDRITIC CELLS; CANCER; EXPRESSION; TOLERANCE; TISSUE;

D O I：

10.3109/07357907.2013.789905

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The epidermal growth factor receptor (EGFR) has a close relation to lung cancer; its role in the pathogenesis of lung cancer is to be further elucidated. The results of this study indicate that about 80% exosomes purified from the LC biopsies contained EGFR; only about 2% exosomes contained EGFR in the samples from chronic lung inflammation. The purified exosomes induced tolerogenic DCs. Coculture of the tolerogenic DCs and Th0 cells generated the tumor antigen-specific regulatory T cells (Treg). The Tregs could suppress the tumor antigen specific CD8(+) T cells.

引用

页码：330 / 335

页数：6

共 21 条

[1] Synthesis and biological evaluation of novel 2,4′-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors [J].

Abou-Seri, Sahar Mahmoud .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) :4113-4121

[2]

[Anonymous], ONCOGENE

[3] Intestinal epithelial cell-derived integrin αβ6 plays an important role in the induction of regulatory T cells and inhibits an antigen-specific Th2 response [J].

Chen, Xiao ;

Song, Chun-Hua ;

Feng, Bai-Sui ;

Li, Tong-Li ;

Li, Ping ;

Zheng, Peng-Yuan ;

Chen, Xian-Ming ;

Xing, Zhou ;

Yang, Ping-Chang .

JOURNAL OF LEUKOCYTE BIOLOGY, 2011, 90 (04) :751-759

[4] Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts [J].

Cho, Jung Ah ;

Park, Ho ;

Lim, Eun Hye ;

Kim, Kye Hyun ;

Choi, Joong Sub ;

Lee, Jung Hoon ;

Shin, Jae Wook ;

Lee, Kyo Won .

GYNECOLOGIC ONCOLOGY, 2011, 123 (02) :379-386

[5] Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression [J].

da Silva, Lucilia ;

Neves, Bruno Miguel ;

Moura, Liane ;

Cruz, Maria Teresa ;

Carvalho, Eugenia .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2011, 1813 (10) :1863-1871

[6] EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples [J].

Ellison, Gillian ;

Zhu, Guanshan ;

Moulis, Alexandros ;

Dearden, Simon ;

Speake, Georgina ;

McCormack, Rose .

JOURNAL OF CLINICAL PATHOLOGY, 2013, 66 (02) :79-89

[7] Indoleamine 2,3-dioxygenase: From catalyst to signaling function [J].

Fallarino, Francesca ;

Grohmann, Ursula ;

Puccetti, Paolo .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (08) :1932-1937

[8] PREVALENCE OF ABERRANT EXPRESSION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN CANCERS [J].

GULLICK, WJ .

BRITISH MEDICAL BULLETIN, 1991, 47 (01) :87-98

[9] Interferon-λ Mediates Oral Tolerance and Inhibits Antigen-Specific, T-Helper 2 Cell-Mediated Inflammation in Mouse Intestine [J].

He, Shao-Heng ;

Chen, Xiao ;

Song, Chun-Hua ;

Liu, Zhi-Qiang ;

Zhou, Lin-Fu ;

Ma, Wen-Jing ;

Zhao, Lei-Di ;

Li, Tong-Li ;

Tang, Shang-Guo ;

Xing, Zhou ;

Yang, Ping-Chang .

GASTROENTEROLOGY, 2011, 141 (01) :249-U336

[10] Indoleamine 2,3-dioxygenase and immune tolerance in ovarian cancer [J].

Ino, Kazuhiko .

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2011, 23 (01) :13-18

← 1 2 3 →