Nickel(II) Dithiocarbamate Complexes Containing Sulforhodamine B as Fluorescent Probes for Selective Detection of Nitrogen Dioxide

被引：66

作者：

Yan, Yan ^{[1
]}

Krishnakumar, Saarangan ^{[1
]}

Yu, Huan ^{[2
]}

Ramishetti, Srinivas ^{[4
]}

Deng, Lih-Wen ^{[3
]}

Wang, Suhua ^{[2
]}

Huang, Leaf ^{[4
]}

Huang, Dejian ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Chinese Acad Sci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China

[3] Natl Univ Hlth Syst, Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore

[4] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 14期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

NITRIC-OXIDE; AQUEOUS-SOLUTION; IMAGING AGENT; METAL;

D O I：

10.1021/ja401555y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We synthesized complexes of Ni(II) with dithiocarbamate ligands derived from the ortho and para isomers of sulforhodamine B fluorophores and demonstrated they are highly selective in reactions with nitrogen dioxide (NO2). Compared with the para isomer, the ortho isomer showed a much greater fluorescence increase upon reaction with NO2, which led to oxidation and decomplexation of the dithiocarbamate ligand from Ni(II). We applied this probe for visual detection of 1 ppm NO2 in the gas phase and fluorescence imaging of NO2 in macrophage cells treated with a nitrogen dioxide donor.

引用

页码：5312 / 5315

页数：4

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