α-Glucosidase inhibitory and cytotoxic botryorhodines from mangrove endophytic fungus Trichoderma sp. 307

被引：28

作者：

Zhang, Liuhong ^{[1
]}

Niaz, Shah Iram ^{[1
]}

Wang, Zhen ^{[2
]}

Zhu, Yonghong ^{[2
]}

Lin, Yongcheng ^{[3
]}

Li, Jing ^{[1
,4
]}

Liu, Lan ^{[1
,4
]}

机构：

[1] Sun Yat Sen Univ, Sch Marine Sci, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Sch Chem, Guangzhou, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, South China Sea Bioresource Exploitat & Utilizat, Guangzhou, Guangdong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 24期

基金：

中国国家自然科学基金;

关键词：

Botryorhodine H; Trichoderma sp; endophytic fungus; alpha-glucosidase inhibitory activity; cytotoxicity;

D O I：

10.1080/14786419.2017.1385023

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

One new depsidone, botryorhodine H (1), together with three known analogues, botryorhodines C, D and G (2-4), were obtained from the mangrove endophytic fungus Trichoderma sp. 307 by co-culturing with Acinetobacter johnsonii B2. Structures were determined by 1D and 2D NMR analyses and high-resolution mass spectrum. Compounds 1-3 showed alpha-glucosidase inhibitory activity with IC50 ranging from 8.1 to 11.2 mu M, and compound 1 exhibited potent cytotoxicity against rat prolactinoma MMQ and rat pituitary adenoma GH3 cell lines (IC50 = 3.09 and 3.64 mu M). [GRAPHICS] .

引用

页码：2887 / 2892

页数：6

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