Tyrphostins .4. Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines

被引：57

作者：

Gazit, A

Chen, J

App, H

McMahon, G

Hirth, P

Chen, I

Levitzki, A

机构：

[1] HEBREW UNIV JERUSALEM, ALEXANDER SILBERMAN INST LIFE SCI, DEPT ORGAN CHEM, IL-91904 JERUSALEM, ISRAEL

[2] HEBREW UNIV JERUSALEM, ALEXANDER SILBERMAN INST LIFE SCI, DEPT BIOL CHEM, IL-91904 JERUSALEM, ISRAEL

[3] SUGEN INC, REDWOOD CITY, CA 94063 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 08期

关键词：

D O I：

10.1016/0968-0896(96)00107-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1203 / 1207

页数：5

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