Expression of Platelet-derived Growth Factor-β Receptor and Bovine Papillomavirus E5 and E7 Oncoproteins in Equine Sarcoid

被引：43

作者：

Borzacchiello, G. ^{[1
]}

Russo, V. ^{[1
]}

Della Salda, L. ^{[2
]}

Roperto, S. ^{[1
]}

Roperto, F. ^{[1
]}

机构：

[1] Univ Naples Federico II, Fac Vet Med, Dept Pathol & Anim Hlth, I-80137 Naples, Italy

[2] Teramo Univ, Fac Vet Med, Dept Comparat Biomed Sci, I-64100 Teramo, Italy

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2008年 / 139卷 / 04期

关键词：

bovine papillomavirus; horse; platelet-derived growth factor-beta receptor; sarcoid;

D O I：

10.1016/j.jcpa.2008.07.006

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Equine sarcoids are benign fibroblastic skin tumours that are recognized throughout the world. Infection with bovine papillomavirus (BPV) types 1 and 2 has been implicated as a major factor in disease development; however the cellular mechanisms underlying fibroblast transformation remain poorly defined. The present study further characterizes aspects of the association with BPV in 15 equine sarcoids. BPV DNA was demonstrated in 12/15 tumours collected from different areas of Italy. Nine of these 12 tumours expressed the BPV oncoproteins E5 and E7, but these oncoproteins were not expressed by normal equine cells. The BPV E5 protein is known to bind to the platelet-derived growth factor-beta receptor (PbGF-beta R) and this molecule was expressed by 11 of the 12 sarcoids in which E5 was demonstrated. These findings add further weight to the theory that BPV and the PDGF-beta R may have a role in the pathogenesis of these disease. (c) 2008 Publislied by Elsevier Ltd.

引用

页码：231 / 237

页数：7

共 37 条

[1] EQUINE CONNECTIVE-TISSUE TUMORS CONTAIN UNINTEGRATED BOVINE PAPILLOMA-VIRUS DNA [J].