Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells

被引：12

作者：

Magedov, Igor V. ^{[1
]}

Lefranc, Florence ^{[2
]}

Frolova, Liliya V. ^{[1
]}

Banuls, Laetitia Moreno Y. ^{[3
]}

Peretti, Amanda S. ^{[4
]}

Rogelj, Snezna ^{[4
]}

Mathieu, Veronique ^{[3
]}

Kiss, Robert ^{[3
]}

Kornienko, Alexander ^{[5
]}

机构：

[1] New Mexico Inst Min & Technol, Dept Chem, Socorro, NM 87801 USA

[2] Univ Libre Brussels, Hop Erasme, Serv Neurochirurg, B-1070 Brussels, Belgium

[3] ULB, Fac Pharm, Lab Toxicol, B-1050 Brussels, Belgium

[4] New Mexico Inst Min & Technol, Dept Biol, Socorro, NM 87801 USA

[5] Texas State Univ San Marcos, Dept Chem & Biochem, San Marcos, TX 78666 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 11期

关键词：

Cancer; Apoptosis resistance; Indole; Antiproliferative; GLIOMA-CELLS; GLIOBLASTOMA; CHEMOTHERAPY; SURVIVAL; MODELS;

D O I：

10.1016/j.bmcl.2013.03.110

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Many types of cancer, including glioma, melanoma, NSCLC, among others, are resistant to apoptosis induction and poorly responsive to current therapies with propaptotic agents. We describe a series of 2,3-disubstituted indoles, which display cytostatic rather than cytotoxic effects in cancer cells, and serve as a new chemical scaffold to develop anticancer agents capable of combating apoptosis-resistant cancers associated with dismal prognoses. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3277 / 3282

页数：6

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