A Role of the Wnt Signaling in the Regulation of Brain Function

被引：1
|
作者：
Gurskaya, O. Ya. [1 ]
Dobryakova, Y. V. [1 ]
Markevich, V. A. [1 ]
机构：
[1] RAS, Inst Higher Nervous Act & Neurophysiol, Moscow, Russia
来源：
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2015年 / 65卷 / 04期
关键词：
Wnt; synaptic plasticity; hippocampus; neurodegenerative diseases; learning and memory; ADENOMATOUS POLYPOSIS-COLI; OBJECT RECOGNITION MEMORY; BETA-CATENIN; SYNAPTIC-TRANSMISSION; TAU-HYPERPHOSPHORYLATION; GENE FAMILY; STEM-CELLS; NEUROGENESIS; DICKKOPF-1; EXPRESSION;
D O I：
10.7868/S0044467715040048
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The review describes the Wnt signaling pathway participation in the embryonic development, such as cell specification, migration and polarity. Recent studies have shown that the Wnt pathway plays one of the key roles in the processes of synaptic plasticity and memory formation. In this review there are evidences of the Wnt cascade involvement in the modulation of synaptic efficacy at both pre- and postsynaptic levels. Here we analyze the role of Wnt ligands in synaptic plasticity and behavior. Finally, we describe that components of Wnt pathways are involved in the development of major neurological and psychiatric disorders, including a neuroprotective role of Wnt proteins in the pathogenesis of Alzheimer's disease.
引用
收藏
页码：387 / 399
页数：13
相关论文
共 50 条
  • [1] Wnt Signaling: Role in Regulation of Haematopoiesis
    Undi, Ram Babu
    Gutti, Usha
    Sahu, Itishri
    Sarvothaman, Shilpa
    Pasupuleti, Satya Ratan
    Kandi, Ravinder
    Gutti, Ravi Kumar
    INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2016, 32 (02) : 123 - 134
  • [2] Wnt signaling pathway - its role in regulation of cell metabolism
    Kozinski, Kamil
    Dobrzyn, Agnieszka
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2013, 67 : 1098 - 1108
  • [3] Wnt signaling in the regulation of adult hippocampal neurogenesis
    Varela-Nallar, Lorena
    Inestrosa, Nibaldo C.
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2013, 7
  • [4] Role of Wnt signaling in synaptic plasticity and memory
    Narvaes, Rodrigo F.
    Furini, Cristiane R. G.
    NEUROBIOLOGY OF LEARNING AND MEMORY, 2022, 187
  • [5] The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer
    Sarkar, Fazlul H.
    Li, Yiwei
    Wang, Zhiwei
    Kong, Dejuan
    CANCER AND METASTASIS REVIEWS, 2010, 29 (03) : 383 - 394
  • [6] Regulation of bone metabolism by the Wnt signaling pathway
    Houschyar, K. S.
    Tapking, C.
    Duscher, D.
    Harati, K.
    Wallner, C.
    Wagner, J. M.
    Maan, Z. N.
    Rein, S.
    Cheliah, M. P.
    Reumuth, G.
    Grieb, G.
    Siemers, F.
    Lehnhardt, M.
    Behr, B.
    HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE, 2019, 51 (04) : 309 - 318
  • [7] The neuroprotective role of Wnt signaling in the retina
    Kassumeh, Stefan
    Weber, Gregor R.
    Nobl, Matthias
    Priglinger, Siegfried G.
    Ohlmann, Andreas
    NEURAL REGENERATION RESEARCH, 2021, 16 (08) : 1524 - 1528
  • [8] Regulation of Wnt/β-Catenin Signaling by Protein Kinases
    Verheyen, Esther M.
    Gottardi, Cara J.
    DEVELOPMENTAL DYNAMICS, 2010, 239 (01) : 34 - 44
  • [9] Postsynaptic Assembly: A Role for Wnt Signaling
    Stamatakou, Eleanna
    Salinas, Patricia C.
    DEVELOPMENTAL NEUROBIOLOGY, 2014, 74 (08) : 818 - 827
  • [10] Role of Wnt Signaling in the Biology of the Periodontium
    Rooker, Scott M.
    Liu, Bo
    Helms, Jill A.
    DEVELOPMENTAL DYNAMICS, 2010, 239 (01) : 140 - 147
12345