Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) of low molecular weight organic compounds and synthetic polymers using zinc oxide (ZnO) nanoparticles

被引：145
作者：
Watanabe, Takehiro [1 ]
Kawasaki, Hideya [1 ]
Yonezawa, Tetsu [2 ]
Arakawa, Ryuichi [1 ]
机构：
[1] Kansai Univ, Dept Appl Chem, Osaka 5648680, Japan
[2] Univ Tokyo, Grad Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan
来源：
JOURNAL OF MASS SPECTROMETRY | 2008年 / 43卷 / 08期
关键词：
surface-assisted laser desorption/ionization (SALDI); ZnO nanoparticles; lipids; synthetic polymers; testosterone; verapamil hydrochloride;
D O I：
10.1002/jms.1385
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed surface-assisted laser desorption/ionization mass spectrometry using zinc oxide (ZnO) nanoparticles with anisotropic shapes (ZnO-SALDI-MS). The mass spectra showed low background noises in the low m/z, i.e. less than 500 u region. Thus, we succeeded in SALDI ionization on low molecular weight organic compounds, such as verapamil hydrochloride, testosterone, and polypropylene glycol (PPG) (average molecular weight 400) without using a liquid matrix or buffers such as citric acids. In addition, we found that ZnO-SALDI has advantages in post-source decay (PSD) analysis and produced a simple mass spectrum for phospholipids. The ZnO-SALDI spectra for synthetic polymers of polyethylene glycol (PEG), polystyrene (PS) and polymethylmethacrylate (PMMA) showed the sensitivity and molecular weight distribution to be comparable to matrix-assisted laser desorption/ionization (MALDI) spectra with a 2,5-dihydroxybenzoic acid (DHB) matrix. ZnO-SALDI shows good performance for synthetic polymers as well as low molecular weight organic compounds. Copyright (C) 2008 John Wiley & Sons, Ltd.
引用
收藏
页码：1063 / 1071
页数：9
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