Preeclampsia and Kidney Disease: Deciphering Cause and Effect

被引:48
作者
Kattah, Andrea [1 ]
机构
[1] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA
关键词
Preeclampsia; Hypertensive disorders of pregnancy; Chronic kidney disease; End-stage kidney disease; ADVERSE PREGNANCY OUTCOMES; GESTATIONAL HYPERTENSION; SUPERIMPOSED PREECLAMPSIA; CARDIOVASCULAR-DISEASE; RENAL-FUNCTION; RISK-FACTORS; WOMEN; PROTEINURIA; PATHOPHYSIOLOGY; MICROALBUMINURIA;
D O I
10.1007/s11906-020-01099-1
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Purpose of Review Preeclampsia and chronic kidney disease have a complex, bidirectional relationship. Women with kidney disease, with even mild reductions in glomerular filtrate rate, have an increased risk of developing preeclampsia. Preeclampsia, in turn, has been implicated in the subsequent development of albuminuria, chronic kidney disease, and end-stage kidney disease. We will discuss observational evidence and mechanisms linking the two disease processes. Recent Findings Preeclampsia is characterized by an imbalance in angiogenic factors that causes systemic endothelial dysfunction. Chronic kidney disease may predispose to the development of preeclampsia due to comorbid conditions, such as hypertension, but is also associated with impaired glycocalyx integrity and alterations in the complement and renin-angiotensin-aldosterone systems. Preeclampsia may lead to kidney disease by causing acute kidney injury, endothelial damage, and podocyte loss. Preeclampsia may be an important sex-specific risk factor for chronic kidney disease. Understanding how chronic kidney disease increases the risk of preeclampsia from a mechanistic standpoint may open the door to future biomarkers and therapeutics for all women.
引用
收藏
页数:11
相关论文
共 89 条
[1]   Validation of fullPIERS model for prediction of adverse outcomes among women with severe pre-eclampsia [J].
Almeida, Silvana T. ;
Katz, Leila ;
Coutinho, Isabela ;
Amorim, Melania M. R. .
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2017, 138 (02) :142-147
[2]   Microalbuminuria after pregnancy complicated by pre-eclampsia [J].
Bar, J ;
Kaplan, B ;
Wittenberg, C ;
Erman, A ;
Boner, G ;
Ben-Rafael, Z ;
Hod, M .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (05) :1129-1132
[3]   Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies [J].
Bartsch, Emily ;
Medcalf, Karyn E. ;
Park, Alison L. ;
Ray, Joel G. .
BMJ-BRITISH MEDICAL JOURNAL, 2016, 353
[4]   Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis [J].
Bellamy, Leanne ;
Casas, Juan-Pablo ;
Hingorani, Aroon D. ;
Williams, David J. .
BMJ-BRITISH MEDICAL JOURNAL, 2007, 335 (7627) :974-977
[5]   Diagnostic and predictive biomarkers for pre-eclampsia in patients with established hypertension and chronic kidney disease [J].
Bramham, Kate ;
Seed, Paul T. ;
Lightstone, Liz ;
Nelson-Piercy, Catherine ;
Gill, Carolyn ;
Webster, Philip ;
Poston, Lucilla ;
Chappell, Lucy C. .
KIDNEY INTERNATIONAL, 2016, 89 (04) :874-885
[6]   Hypertensive Disorders of Pregnancy ISSHP Classification, Diagnosis, and Management Recommendations for International Practice [J].
Brown, Mark A. ;
Magee, Laura A. ;
Kenny, Louise C. ;
Karumanchi, S. Ananth ;
McCarthy, Fergus P. ;
Saito, Shigeru ;
Hall, David R. ;
Warren, Charlotte E. ;
Adoyi, Gloria ;
Ishaku, Salisu .
HYPERTENSION, 2018, 72 (01) :24-43
[7]   Eculizumab for the treatment of preeclampsia/HELLP syndrome [J].
Burwick, R. M. ;
Feinberg, B. B. .
PLACENTA, 2013, 34 (02) :201-203
[8]   Terminal Complement Activation in Preeclampsia [J].
Burwick, Richard M. ;
Velasquez, Jesus A. ;
Valencia, Catalina M. ;
Gutierrez-Marin, Jorge ;
Edna-Estrada, Francisco ;
Silva, Jaime L. ;
Trujillo-Otalvaro, Juliana ;
Vargas-Rodriguez, Johanna ;
Bernal, Yamile ;
Quintero, Alvaro ;
Rincon, Monica ;
Tolosa, Jorge E. .
OBSTETRICS AND GYNECOLOGY, 2018, 132 (06) :1477-1485
[9]   Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis [J].
Coca, Steven G. ;
Singanamala, Swathi ;
Parikh, Chirag R. .
KIDNEY INTERNATIONAL, 2012, 81 (05) :442-448
[10]   Diagnostic accuracy of urinary spot protein:creatinine ratio for proteinuria in hypertensive pregnant women:: systematic review [J].
Cote, Anne-Marie ;
Brown, Mark A. ;
Lam, Elaine ;
von Dadelszen, Peter ;
Firoz, Tabassum ;
Liston, Robert M. ;
Magee, Laura A. .
BRITISH MEDICAL JOURNAL, 2008, 336 (7651) :1003-1006