A presynaptic gain control mechanism fine-tunes olfactory behavior

被引：249

作者：

Root, Cory M. ^{[1
]}

Masuyama, Kaoru ^{[1
]}

Green, David S. ^{[1
]}

Enell, Lina E. ^{[2
]}

Nassel, Dick R. ^{[2
]}

Lee, Chi-Hon ^{[3
]}

Wang, Jing W. ^{[1
]}

机构：

[1] Univ Calif San Diego, Neurobiol Sect, Div Biol Sci, La Jolla, CA 92093 USA

[2] Stockholm Univ, Dept Zool, S-10691 Stockholm, Sweden

[3] NICHHD, NIH, Bethesda, MD 20892 USA

来源：

NEURON | 2008年 / 59卷 / 02期

关键词：

D O I：

10.1016/j.neuron.2008.07.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Early sensory processing can play a critical role in sensing environmental cues. We have investigated the physiological and behavioral function of gain control at-the first synapse of olfactory processing in Drosophila. Olfactory receptor neurons (ORNs) express the GABA(B) receptor (GABA(B)R), and its expression expands the dynamic range of ORN synaptic transmission that is preserved in projection neuron responses. Strikingly, each ORN channel has a unique baseline level of GABA(B)R expression. ORNs that sense the aversive odorant CO2 do not express GABA(B)Rs and do not have significant pre-synaptic inhibition. In contrast, pheromone-sensing ORNs express a high level of GABA(B)Rs and exhibit strong presynaptic inhibition. Furthermore, pheromone-dependent mate localization is impaired in flies that lack GABA(B)Rs in specific ORNs. These findings indicate that different olfactory receptor channels employ heterogeneous presynaptic gain control as a mechanism to allow an animal's innate behavioral responses to match its ecological needs.

引用

页码：311 / 321

页数：11

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