DISTRIBUTION OF CYCLIC AND ACYCLIC BIS-BIBENZYLS IN THE MARCHANTIOPHYTA (LIVERWORTS), FERNS AND HIGHER PLANTS AND THEIR BIOLOGICAL ACTIVITIES, BIOSYNTHESIS, AND TOTAL SYNTHESIS

被引：30
作者：
Asakawa, Yoshinori [1 ]
Ludwiczuk, Agnieszka [1 ,2 ]
机构：
[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan
[2] Med Univ Lublin, Med Plant Unit, Dept Pharmacognosy, PL-20093 Lublin, Poland
来源：
HETEROCYCLES | 2012年 / 86卷 / 02期
关键词：
Liverwort; Bis-bibenzyl; Biological Activity; Biosynthesis; Total Synthesis; CHLORINATED MACROCYCLIC BISBIBENZYLS; CHEMICAL-CONSTITUENTS; RICCARDIN-C; PLAGIOCHIN-E; SESQUITERPENE LACTONES; MULTIDRUG-RESISTANCE; MALAGASY LIVERWORTS; BIS(BIBENZYL ETHER); AROMATIC-COMPOUNDS; DERIVATIVES;
D O I：
10.3987/REV-12-SR(N)5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Marchantiophyta (liverworts) are rich sources of cyclic and acyclic bis-bibenzyls which are very rare natural products in the plant kingdom. At present more than 70 of bis-bibenzyls have been found in liverworts. The structurally unique cyclic and acyclic bis-bibenzyls shows various biological activities such as antimicrobial, antifungal, cytotoxicity, antiobesitic, muscle relaxation, antitripanosomal activity, among others. They are biosynthesized from dimerization of lunularic acid via dihydrocoumaric acid and prelunularin. The present paper deals with the distribution of bis-bibenzyls in liverworts, fern and higher plants and their biological activity, biosynthesis, and total synthesis
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页码：891 / 917
页数：27
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