Association between the C804A polymorphism in the TGF-β gene and the risk of myocardial infarction: a meta-analysis

被引：1

作者：

Suo, D. W. ^{[1
]}

Hu, Q. ^{[1
]}

Chen, J. ^{[1
]}

Sun, Q. H. ^{[1
]}

Guo, H. ^{[1
]}

机构：

[1] Zhengzhou Univ, Hosp 5, Dept Emergency, Zhengzhou 450052, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 01期

关键词：

Meta-analysis; Myocardial infarction; Polymorphism; TNF-beta; LYMPHOTOXIN-ALPHA GENE; SNPS; HETEROGENEITY; CANCER; BIAS;

D O I：

10.4238/2015.March.6.4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor necrosis factor-beta (TNF-beta) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-beta gene and MI risk, their results are controversial and ambiguous. In this study, we evaluated the contribution of the TNF-beta C804A polymorphism to MI risk. A literature search was conducted in the PubMed, Embase, Web of Science, Cochrane Library, and Google Scholar databases to identify eligible studies published before November 1, 2013. We performed a meta-analysis of 9 case-control studies, which included a total of 19,404 MI patients and 13,684 healthy controls. Overall analysis suggested that the TNF-beta C804A polymorphism was associated with a significantly increased risk of MI. Stratified analysis based on ethnicity revealed a significant association in Asian populations, but not in Caucasian populations. In conclusion, this meta-analysis revealed that the TNF-beta C804A polymorphism may be associated with an increased risk of MI only in Asian populations. However, additional studies should be conducted to further confirm the association between TNF-beta C804A and MI risk.

引用

页码：1566 / 1579

页数：14

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