Effects of illness activity on electrocardiographic parameters in patient with multiple sclerosis

Background: Multiple sclerosis (MS) has been reported to be associated with autonomic dysfunction. QT and P wave duration are clearly related to autonomic nervous system. We compared P wave dispersion (PWD) and corrected QT dispersion (QTcD) in stable phase and active phase MS patients to healthy control subjects. Method: 76 MS patients and44 healthy control subjects were included. Twelve-lead surface ECG recording was performed all participants. The P and QT wave parameters were measured manually Results: Maximum P wave and QTc duration were higher in MS patients than control groups. The average PWD and QTcD value of MS patients was also found to be higher than control groups. According to illness activity, statistically differences weren't observed at ECG parameters in patients with MS. Conclusion: P wave and QTc duration were found to be statistically different in patients with MS and control subjects. But illness activity didn't affect these electrocardiographic parameters as significantly.