Effect of Neoadjuvant Chemoradiotherapy on Lymph Node Micrometastases in Thoracic Esophageal Cancer

被引：9

作者：

Yanagi, Masayuki ^{[1
,2
]}

Sasaki, Ken ^{[1
]}

Uchikado, Yasuto ^{[1
]}

Omoto, Itaru ^{[1
]}

Arigami, Takaaki ^{[1
]}

Kurahara, Hiroshi ^{[1
]}

Uenosono, Yoshikazu ^{[1
]}

Sakoda, Masahiko ^{[1
]}

Maemura, Kosei ^{[1
]}

Natsugoe, Shoji ^{[1
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Digest Surg Breast & Thyroid Surg, Sakuragaoka 8-35-1, Kagoshima, Kagoshima 8908520, Japan

[2] Kagoshima City Hosp, Dept Gastoenter Surg, Kagoshima, Japan

来源：

ANTICANCER RESEARCH | 2018年 / 38卷 / 02期

关键词：

Lymph node metastasis; lymph node micrometastasis; cytokeratin; neoadjuvant chemoradiotherapy; esophageal cancer; randomized controlled trial; SQUAMOUS-CELL CARCINOMA; CLINICAL-SIGNIFICANCE; TUMOR-CELLS; CHEMOTHERAPY; METASTASIS; SURGERY; MICROINVOLVEMENT; PROGNOSIS; THERAPY; IMPACT;

D O I：

10.21873/anticanres.12299

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: The purpose of this study was to clarify the effect of neoadjuvant chemoradiotherapy (nCRT) on lymph node micrometastasis (LNM) in esophageal squamous cell carcinoma (ESCC). Patients and Methods: The therapeutic efficacy of nCRT was analyzed in 41 ESCC patients randomized to the Surgery group (n=21) and the nCRT group (n=20). Lymph node specimens from patients were classified into two categories, micrometastasis (MM) and tumor cell microinvolvement (MI), after immunohistochemical evaluation. Results: The incidence rates of patients presenting MM with or without MI or MI alone in the Surgery group were significantly higher than those in the nCRT group. The 10-year survival rate of 15 patients with simultaneous histological metastasis (HM) and LNM was significantly lower than that in the 26 patients without LNM. Within the nCRT group, the 10-year survival rates of patients with versus those without HM were not significantly different; however, the 10-year survival rate of the 5 patients with simultaneous HM and LNM was significantly lower than that of the 15 patients without LNM. Conclusion: ESCC patients with LNM may benefit from nCRT, and evaluation of the simultaneous presence of HM and LNM may facilitate accurate prediction of survival in ESCC patients.

引用

页码：893 / 900

页数：8

共 24 条

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