Making β cells from adult tissues

被引：19

作者：

Efrat, Shimon ^{[1
]}

Russ, Holger A. ^{[2
]}

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Dept Human Mol Genet & Biochem, IL-69978 Tel Aviv, Israel

[2] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2012年 / 23卷 / 06期

基金：

以色列科学基金会;

关键词：

EMBRYONIC STEM-CELLS; INSULIN-PRODUCING CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; LINEAGE TRACING EVIDENCE; IN-VITRO; DIRECT CONVERSION; HUMAN FIBROBLASTS; HUMAN PANCREAS; DOPAMINERGIC-NEURONS; MOUSE FIBROBLASTS;

D O I：

10.1016/j.tem.2012.03.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

beta-Cell replacement represents an attractive prospect for diabetes therapy. Although much hope has been placed on derivation of insulin-producing cells from human pluripotent stem cells, this approach continues to face considerable challenges. Cells from adult human tissues, with both stem/progenitor and mature phenotypes, offer a possible alternative. This review summarizes recent progress in two major strategies based on this cell source, ex vivo expansion of human islet beta cells and conversion of non-beta cells into insulin-producing cells by nuclear reprogramming, and examines the obstacles that remain to be overcome for bringing these strategies closer to clinical application in diabetes therapy.

引用

页码：278 / 285

页数：8

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