Environmental Factors Involved in Maternal Morbidity and Mortality

被引：31

作者：

Boyles, Abee L. ^{[1
]}

Beverly, Brandiese E. ^{[2
]}

Fenton, Suzanne E. ^{[2
]}

Jackson, Chandra L. ^{[3
,4
]}

Jukic, Anne Marie Z. ^{[3
]}

Sutherland, Vicki L. ^{[2
]}

Baird, Donna D. ^{[3
]}

Collman, Gwen W. ^{[1
]}

Dixon, Darlene ^{[2
]}

Ferguson, Kelly K. ^{[3
]}

Hall, Janet E. ^{[5
]}

Martin, Elizabeth M. ^{[6
,7
]}

Schug, Thaddeus T. ^{[1
]}

White, Alexandra J. ^{[3
]}

Chandler, Kelly J. ^{[8
]}

机构：

[1] NIEHS, Div Extramural Res & Training, US Dept Hlth & Human Serv, NIH, POB 12233 Mail Drop K3-04, Durham, NC 27709 USA

[2] NIEHS, Natl Toxicol Program, US Dept Hlth & Human Serv, NIH, Durham, NC 27709 USA

[3] NIEHS, Epidemiol Branch, US Dept Hlth & Human Serv, NIH, Durham, NC 27709 USA

[4] Natl Inst Minor Hlth & Hlth Dispar, Intramural Program, US Dept Hlth & Human Serv, NIH, Bethesda, MD USA

[5] NIEHS, Clin Res Branch, US Dept Hlth & Human Serv, NIH, Durham, NC 27709 USA

[6] NIEHS, Epigenet & Stem Cell Biol Lab, US Dept Hlth & Human Serv, NIH, Durham, NC 27709 USA

[7] NIGMS, Postdoctoral Res Associate Training Program, US Dept Hlth & Human Serv, NIH, Bethesda, MD USA

[8] NIEHS, Off Policy Planning & Evaluat, US Dept Hlth & Human Serv, NIH, Durham, NC 27709 USA

来源：

JOURNAL OF WOMENS HEALTH | 2021年 / 30卷 / 02期

基金：

美国国家卫生研究院;

关键词：

environmental exposures; maternal health; window of susceptibility; air pollution; endocrine-disrupting chemical; MAMMARY-GLAND DEVELOPMENT; AMBIENT AIR-POLLUTION; BISPHENOL-A; HYPERTENSIVE DISORDERS; PHTHALATE METABOLITES; PREGNANT-WOMEN; PFOA EXPOSURE; BLOOD LEAD; RISK; BREAST;

D O I：

10.1089/jwh.2020.8855

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Nongenetic, environmental factors contribute to maternal morbidity and mortality through chemical exposures via air, water, soil, food, and consumer products. Pregnancy represents a particularly sensitive window of susceptibility during which physiological changes to every major organ system increase sensitivity to chemicals that can impact a woman's long-term health. Nonchemical stressors, such as low socioeconomic status, may exacerbate the effects of chemical exposures on maternal health. Racial/ethnic minorities are exposed disproportionately to both chemicals and nonchemical stressors, which likely contribute to the observed health disparities for maternal morbidities and mortality. Epidemiological studies linking exposures to adverse maternal health outcomes underscore the importance of environmental health impacts, and mechanistic studies in model systems reveal how chemicals perturb biological pathways and processes. Environmental stressors are associated with a variety of immediate maternal health impacts, including hypertensive disorders of pregnancy, fibroids, and infertility, as well as long-term maternal health impacts, such as higher risk of breast cancer and metabolic disorders. Identifying and reducing a pregnant woman's environmental exposures is not only beneficial to her offspring but also important to preserve her short- and long-term health.

引用

页码：245 / 252

页数：8