Nitric Oxide Releasing Photoresponsive Nanohybrids As Excellent Therapeutic Agent for Cervical Cancer Cell Lines

被引：33
|
作者：
Sudhesh, Priya [1 ]
Tamilarasan, Kaviyarasan [1 ]
Arumugam, Palaniappan [1 ]
Berchmans, Sheela [1 ]
机构：
[1] CSIR Cent Electrochem Res Inst, Electrod & Electrocatalysis Div, Karaikkudi 630006, Tamil Nadu, India
来源：
ACS APPLIED MATERIALS & INTERFACES | 2013年 / 5卷 / 17期
关键词：
photoresponsive; nanohybrids; 2-mercapto-5-nitrobenzimidazole (MNBI); gold nanoparticles (GNP); nitric oxide (NO); apoptosis; NANOPARTICLES; FLUTAMIDE; SURFACE;
D O I：
10.1021/am402086m
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Gold nanoparticles (GNPs) that can release nitric oxide (NO) on visible-light irradiation were prepared using 2-mercapto-5-nitro benzimidazole (MNBI) as stabilizer. These nanoparticles meet overall prerequisites for biomedical applications like small sizes, water solubility, and stability. It was found that even a very low dosage of MNBI-stabilized GNPs exhibit appreciable tumor cell mortality against cervical cancer cell lines, demonstrating the role of NO in killing cancer cells.
引用
收藏
页码：8263 / 8266
页数：4
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