Convergent Chemical Synthesis of Histone H2B Protein for the Site-Specific Ubiquitination at Lys34

被引:110
|
作者
Siman, Peter [1 ]
Karthikeyan, Subramanian Vedhanarayanan [1 ]
Nikolov, Miroslav [2 ]
Fischle, Wolfgang [2 ]
Brik, Ashraf [1 ]
机构
[1] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel
[2] Max Planck Inst Biophys Chem, Lab Chromatin Biochem, D-37077 Gottingen, Germany
基金
以色列科学基金会;
关键词
chromatin; H2B protein; peptide ligation; proteins; ubiquitination; LIGATION; STRATEGY; UBIQUITYLATION; METHYLATION; CROSSTALK; EFFICIENT; PEPTIDES; CYSTEINE;
D O I
10.1002/anie.201303844
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:8059 / 8063
页数:5
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