Nanostructure-induced DNA condensation

被引：48
|
作者：
Zhou, Ting [1 ,2 ]
Llizo, Axel [1 ,3 ]
Wang, Chen [1 ]
Xu, Guiying [2 ]
Yang, Yanlian [1 ]
机构：
[1] Natl Ctr Nanosci & Technol NCNST, Beijing 100190, Peoples R China
[2] Shandong Univ, Key Lab Colloid & Interface Chem, Minist Educ, Jinan 250100, Peoples R China
[3] Ctr Estudios Avanzados Cuba, Havana 19370, Cuba
来源：
NANOSCALE | 2013年 / 5卷 / 18期
关键词：
ATOMIC-FORCE MICROSCOPY; NONVIRAL GENE DELIVERY; CARBON NANOTUBES; GOLD NANOPARTICLES; SINGLE-MOLECULE; PLASMID DNA; GEMINI SURFACTANTS; NUCLEIC-ACIDS; TRANSFECTION EFFICIENCY; STRUCTURAL TRANSITIONS;
D O I：
10.1039/c3nr01630g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The control of the DNA condensation process is essential for compaction of DNA in chromatin, as well as for biological applications such as nonviral gene therapy. This review endeavours to reflect the progress of investigations on DNA condensation effects of nanostructure-based condensing agents (such as nanoparticles, nanotubes, cationic polymer and peptide agents) observed by using atomic force microscopy (AFM) and other techniques. The environmental effects on structural characteristics of nanostructure-induced DNA condensates are also discussed.
引用
收藏
页码：8288 / 8306
页数：19
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