Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue

The protective effect of magnesium as magnesium sulfate (MS) on sodium-metavanadate-(SMV-) induced lipid peroxidation (LPO) under in vivo and in vitro conditions was studied. The 18-week SMV intoxication (Group II, 0.125 V-end/mL) enhanced spontaneous malondialdehyde (MDA) generation in rat liver, compared with the control (Group I) and MS-supplemented animals (Group III, 0.06 Mg-end/mL). Coadministration of SMV with MS (Group IV, SMV-MS) caused a return of the MDA level to the control value range. The effect seems to result from the Mg-end-independent action and its antagonistic interaction with V-end. The in vitro treatment of liver supernatants (LS) obtained from all the tested animals groups with selected exogenous concentrations of Fe-exg or V-exg exhibited enhanced MDA production, compared with spontaneously formed MDA. It also showed Mg-exg-stimulating effect on LPO (LS I, Group I) and revealed that the changes in the MDA generation in LS IV (Group IV) might have resulted from the synergistic interactions of V-end with Fe-exg and V-exg and from the antagonistic interactions of Mg-end with Fe-exg and V-exg. The findings allow a suggestion that adequate Mg intake for a specific period in the conditions of SMV exposure may prevent V-induced LPO in the liver.