Casein-derived antimicrobial peptides generated by Lactobacillus acidophilus DPC6026

被引：178
作者：
Hayes, A
Ross, RP
Fitzgerald, GF
Hill, C
Stanton, C
机构：
[1] TEAGASC, Moorepk Food Res Ctr, Fermoy, Cork, Ireland
[2] Natl Univ Ireland Univ Coll Cork, Dept Microbiol, Cork, Ireland
[3] Alimentary Pharmabiot Ctr, Cork, Ireland
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2006年 / 72卷 / 03期
关键词：
D O I：
10.1128/AEM.72.3.2260-2264.2006
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Three peptides produced by a Lactobacillus acidophilus DPC6026 fermentation of sodium caseinate and showing antibacterial activity against pathogenic strains Enterobacter sakazakii ATCC 12868 and Escherichia coli DPC5063 were characterized. These peptides were all generated from bovine alpha(s1)-casein and identified as IKHQGLPQE, VLNENLLR, and SDIPNPIGSENSEK. These peptides may have bioprotective applicability and potential use in milk-based formula, which has been linked to E. sakazakii infection in neonates.
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收藏
页码：2260 / 2264
页数：5
相关论文
共 24 条
  • [1] MECHANISMS OF ACTION ON ESCHERICHIA-COLI OF CECROPIN-P1 AND PR-39, 2 ANTIBACTERIAL PEPTIDES FROM PIG INTESTINE
    BOMAN, HG
    AGERBERTH, B
    BOMAN, A
    [J]. INFECTION AND IMMUNITY, 1993, 61 (07) : 2978 - 2984
  • [2] DEPALENCIA F, 1997, J AGR FOOD CHEM, V45, P95
  • [3] Dziuba J, 1999, NAHRUNG, V43, P190, DOI [10.1002/(SICI)1521-3803(19990601)43:3&lt
  • [4] 190::AID-FOOD190&gt
  • [5] 3.0.CO
  • [6] 2-A, 10.1002/(SICI)1521-3803(19990601)43:3<190::AID-FOOD190>3.3.CO
  • [7] 2-1]
  • [8] Mode of action of the antimicrobial peptide indolicidin
    Falla, TJ
    Karunaratne, DN
    Hancock, REW
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (32) : 19298 - 19303
  • [9] Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks started by Lactobacillus delbrueckii subsp bulgaricus SS1 and Lactococcus lactis subsp cremoris FT4
    Gobbetti, M
    Ferranti, P
    Smacchi, E
    Goffredi, F
    Addeo, F
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2000, 66 (09) : 3898 - 3904
  • [10] Latent bioactive peptides in milk proteins: Proteolytic activation and significance in dairy processing
    Gobetti, M
    Stepaniak, L
    De Angelis, M
    Corsetti, A
    Di Cagno, R
    [J]. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2002, 42 (03) : 223 - 239
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