Expression of Activin Receptor-like Kinase 7 in Adipose Tissues

被引：11
|
作者：
Murakami, Masaru [1 ]
Shirai, Mitsuyuki [2 ]
Ooishi, Ryo [1 ]
Tsuburaya, Asako [1 ]
Asai, Kumiko [1 ]
Hashimoto, Osamu [3 ]
Ogawa, Kenji [4 ]
Nishino, Yoshii [5 ]
Funaba, Masayuki [6 ]
机构：
[1] Azabu Univ, Sch Vet Med, Mol Biol Lab, Sagamihara, Kanagawa 2525201, Japan
[2] Azabu Univ, Sch Vet Med, Lab Vet Pharmacol, Sagamihara, Kanagawa 2525201, Japan
[3] Kitasato Univ, Sch Vet Med, Lab Expt Anim Sci, Towada, Aomori 0348628, Japan
[4] RIKEN, ASI, Chem Genom Res Grp, Wako, Saitama 3510198, Japan
[5] Kyoto Sangyo Univ, Fac Life Sci, Dept Anim Med Sci, Kyoto 6038555, Japan
[6] Kyoto Univ, Grad Sch Agr, Div Appl Biosci, Kyoto 6068502, Japan
来源：
BIOCHEMICAL GENETICS | 2013年 / 51卷 / 3-4期
基金：
日本学术振兴会;
关键词：
Alk7; Tgf-beta family; Variants; Adipose tissue; GROWTH-FACTOR-BETA; SERINE/THREONINE KINASE; BROWN ADIPOCYTES; ALK7; PROTEIN; MOUSE; IDENTIFICATION; SUPERFAMILY; SPECIFICITY; ISOFORMS;
D O I：
10.1007/s10528-012-9555-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The tissue distribution of activin receptor-like kinase 7 (Alk7) expression, the signaling ability of Alk7 variants, and Alk7 expression in response to beta(3)-adrenergic receptor activation were examined. Expression levels of Alk7 varied greatly among tissues but were highest in white adipose tissue and brown adipose tissue. In addition to full-length Alk7 (Alk7-v1), Alk7-v3, an Alk7 variant, was expressed in adipose tissues, brain, and ovary. Nodal transmits signals via Alk7 in cooperation with its coreceptor, Cripto. Evaluation of the ability of Alk7 variants to confer Nodal signaling using luciferase-based reporter assays showed that Alk7-v3 does not transmit Nodal-Cripto-mediated signals. Expression of Alk7 was down-regulated in brown but not in white adipose tissue treated with CL316,243, a beta(3)-adrenergic receptor agonist. These results suggest involvement of Alk7 in modulation of metabolism in the adipose tissues in response to beta(3)-adrenergic receptor activation.
引用
收藏
页码：202 / 210
页数：9
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