Enantioseparation of Substituted 1, 3-Diazaspiro [4.5]Decan-4-Ones: HPLC Comparative Study on Different Polysaccharide Type Chiral Stationary Phases
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作者:
Aboul-Enein, Hassan Y.
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Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, Egypt
Aboul-Enein, Hassan Y.
[1
]
Aboul-Enein, Mohamed N.
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Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, Egypt
Aboul-Enein, Mohamed N.
[1
]
El-Azzouny, Aida A.
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Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, Egypt
El-Azzouny, Aida A.
[1
]
Saleh, Ola A.
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Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, Egypt
Saleh, Ola A.
[1
]
Hassan, Rasha M.
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Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, Egypt
Hassan, Rasha M.
[1
]
Amin, Kamilia M.
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Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, EgyptNatl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, Egypt
Amin, Kamilia M.
[2
]
机构:
[1] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Giza 12622, Egypt
[2] Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt
Enantioseparation of substituted 1,3-diazaspiro[4.5]decan-4-ones (1-14) was achieved using different polysaccharide type chiral stationary phases (CSPs), namely, Chiralcel OJ, Chiralcel OD and Lux-Amylose-2 using different mobile phases which were either n-hexane/2-propanol or n-hexane/ethanol mixtures of various ratios (v/v) at flow rate 1 mL min(-1). UV detection was carried out at 254 nm and temperature of 20A degrees C. The retention behavior and selectivity of these CSPs were examined in isocratic normal phase high-performance liquid chromatography mode. The results revealed that the amylose CSP (Lux-Amylose-2) could separate almost all the compounds under investigation in contrast to cellulose CSPs (Chiracel OJ and Chiracel OD) which resolved fewer compounds.
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King Faisal Specialist Hosp & Res Ctr, Pharmaceut Anal Lab, Biol & Med Res Dept MBC 03, Riyadh 11211, Saudi ArabiaKing Faisal Specialist Hosp & Res Ctr, Pharmaceut Anal Lab, Biol & Med Res Dept MBC 03, Riyadh 11211, Saudi Arabia
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Natl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
Aboul-Enein, Mohamed Nabil
El-Azzouny, Aida Abdel Sattar
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Natl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
El-Azzouny, Aida Abdel Sattar
Saleh, Ola Ahmed
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Natl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
Saleh, Ola Ahmed
Amin, Kamilia Mahmoud
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Cairo Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
Amin, Kamilia Mahmoud
Maklad, Yousreya Ali
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Natl Res Ctr, Pharmaceut & Med Chem Dept, Pharmacol Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
Maklad, Yousreya Ali
Hassan, Rasha Mohamed
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Natl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
机构:
King Faisal Specialist Hosp & Res Ctr, Pharmaceut Anal Lab, Biol & Med Res Dept MBC 03, Riyadh 11211, Saudi ArabiaKing Faisal Specialist Hosp & Res Ctr, Pharmaceut Anal Lab, Biol & Med Res Dept MBC 03, Riyadh 11211, Saudi Arabia
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Natl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
Aboul-Enein, Mohamed Nabil
El-Azzouny, Aida Abdel Sattar
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Natl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
El-Azzouny, Aida Abdel Sattar
Saleh, Ola Ahmed
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机构:
Natl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
Saleh, Ola Ahmed
Amin, Kamilia Mahmoud
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机构:
Cairo Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
Amin, Kamilia Mahmoud
Maklad, Yousreya Ali
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h-index: 0
机构:
Natl Res Ctr, Pharmaceut & Med Chem Dept, Pharmacol Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
Maklad, Yousreya Ali
Hassan, Rasha Mohamed
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h-index: 0
机构:
Natl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, EgyptNatl Res Ctr, Pharmaceut & Med Chem Dept, Med Chem Grp, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt