Whole Milk Increases Intestinal ANGPTL4 Expression and Excretion of Fatty Acids through Feces and Urine

被引：8
|
作者：
Nielsen, Soren Drud [1 ]
Amer, Bashar [1 ]
Blaabjerg, Karoline [2 ]
Dalsgaard, Trine K. [1 ]
Jessen, Randi [1 ]
Petrat-Melin, Bjorn [1 ]
Rasmussen, Martin Kroyer [1 ]
Poulsen, Hanne D. [2 ]
Young, Jette F. [1 ]
机构：
[1] Aarhus Univ, Dept Food Sci, DK-8830 Tjele, Denmark
[2] Aarhus Univ, Dept Anim Sci, DK-8830 Tjele, Denmark
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2017年 / 65卷 / 02期
关键词：
fatty acids; secretion; uptake; ANGPTL4; feces; urine; intestine; milk; ANGIOPOIETIN-LIKE; 4; DIETARY CALCIUM; ENERGY-EXPENDITURE; DAIRY-PRODUCTS; BLOOD-LIPIDS; SERUM; ABSORPTION; OBESITY; DERIVATIZATION; DIGESTIBILITY;
D O I：
10.1021/acs.jafc.6b04135
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The angiopoietin-like 4 (ANGPLT4) proteiriqS involved in lipid metabolism and is known to inhibit lipoprotein lipase in the bloodstream. We investigated the effect of milk on intestinal-ANGPTL4 and the metabolic profile of growing pigs and the effect of free fatty acids (FFAS) on ANGPTL4 in ex -vivo and in vitro assays. Feding pigs whole milk increased intestinal ANGPTL4 mRNA and increased fecal excretion of long-chain FFA compared to the control group fed soybean oil (n = 9). Furthermore, FFAs (C4-C8) induced ANGPTL4 gene expression in porcine intestinal tissue mounted in Ussing chambers -.and ANGPTL4 protein secretion to both the apical and 'bascilateral sides of intestinal Caco-2 cells on permeable men-ibranes. Altogether, these results support an ANGPTL4-induced secretion of fecal FFAs. Urinary levels of FFAs (C4-C12), 3-hydroxyadipic acid, and suberic acid were also increased by milk consumption, indicating higher energy expenditure compared to the control group.
引用
收藏
页码：281 / 290
页数：10
相关论文
共 37 条
  • [1] Medium chain fatty acids from milk induce angiopoietin-like 4 (ANGPTL4) gene expression
    Nielsen, Soren D.
    Amer, Bashar
    Young, Jette F.
    Mortensen, Grith
    Petersen, Rasmus K.
    Kristiansen, Karsten
    Dalsgaard, Trine K.
    INTERNATIONAL DAIRY JOURNAL, 2015, 42 : 34 - 41
  • [2] Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by PPARβ/δ and Protects Against Oxidative Stress
    Georgiadi, Anastasia
    Lichtenstein, Laeticia
    Degenhardt, Tatjana
    Boekschoten, Mark
    van Bilsen, Marc
    Desvergne, Beatrice
    Mueller, Michael
    Kersten, Sander
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (07) : E30 - E30
  • [3] Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids
    Chen, Yan Q.
    Pottanat, Thomas G.
    Siegel, Robert W.
    Ehsani, Mariam
    Qian, Yue-Wei
    Zhen, Eugene Y.
    Regmi, Ajit
    Roell, William C.
    Guo, Haihong
    Luo, M. Jane
    Gimeno, Ruth E.
    van't Hooft, Ferdinand
    Konrad, Robert J.
    JOURNAL OF LIPID RESEARCH, 2020, 61 (08) : 1203 - 1220
  • [4] ANGPTL4 expression induced by butyrate and rosiglitazone in human intestinal epithelial cells utilizes independent pathways
    Korecka, Agata
    de Wouters, Tomas
    Cultrone, Antonietta
    Lapaque, Nicolas
    Pettersson, Sven
    Dore, Joel
    Blottiere, Herve M.
    Arulampalam, Velmurugesan
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2013, 304 (11): : G1025 - G1037
  • [5] Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids
    Kersten, Sander
    Lichtenstein, Laeticia
    Steenbergen, Emma
    Mudde, Karin
    Hendriks, Henk F. J.
    Hesselink, Matthijs K.
    Schrauwen, Patrick
    Muller, Michael
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (06) : 969 - U466
  • [6] Fatty Acids and Hypoxia Stimulate the Expression and Secretion of the Adipokine ANGPTL4 (Angiopoietin-Like Protein 4/Fasting-Induced Adipose Factor) by Human Adipocytes
    Gonzalez-Muniesa, Pedro
    de Oliveira, Cristiane
    de Heredia, Fatima Perez
    Thompson, Mary P.
    Trayhurn, Paul
    JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS, 2011, 4 (03) : 146 - 153
  • [7] Growth hormone upregulates ANGPTL4 mRNA and suppresses lipoprotein lipase via fatty acids: Randomized experiments in human individuals
    Hjelholt, Astrid Johannesson
    Sondergaard, Esben
    Pedersen, Steen Bonlokke
    Moller, Niels
    Jessen, Niels
    Jorgensen, Jens Otto L.
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2020, 105
  • [8] Geiparvarin Inhibits OS Metastasis through Upregulation of ANGPTL4 Expression by Inhibiting miRNA-3912-3p Expression
    Jiang, Fuling
    Wang, Guang-Jie
    Huang, Ping
    Chen, Shu
    Xiao, He
    Zhang, Liang
    Zou, Hua
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
  • [9] INFLUENCE OF FEEDING ON CERTAIN ACIDS IN FECES OF INFANTS IV. THE EFFECT OF AN EXCESS OF LACTOSE IN BREAST MILK AND IN WHOLE COWS MILK ON THE EXCRETION OF VOLATILE ACIDS AND OF LACTIC ACID
    Gerstley, Jesse R.
    Wang, Chi Che
    Wood, Agnes A.
    AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1930, 39 (04): : 729 - 735
  • [10] INFLUENCE OF FEEDING ON CERTAIN ACIDS IN FECES OF INFANTS III. A COMPARISON OF THE EFFECTS OF BREAST MILK AND OF WHOLE COW'S MILK ON THE EXCRETION OF VOLATILE ACIDS AND OF LACTIC ACID
    Gerstley, Jesse R.
    Wang, Chi Che
    Wood, Agnes A.
    AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1930, 39 (03): : 487 - 492
1234