Heparanase: Multiple functions in inflammation, diabetes and atherosclerosis

被引:47
作者
Vlodavsky, Israel [1 ,2 ]
Iozzo, Renato V. [3 ]
Sanderson, Ralph D. [4 ]
机构
[1] Technion Israel Inst Technol, Rappaport Fac Med, Canc & Vasc Biol Res Ctr, Haifa, Israel
[2] Technion Israel Inst Technol, Res Inst, Haifa, Israel
[3] Thomas Jefferson Univ, Kimmel Canc Ctr, Canc Cell Biol & Signaling Program, Philadelphia, PA 19107 USA
[4] Univ Alabama Birmingham, Ctr Comprehens Canc, Dept Pathol, Birmingham, AL 35294 USA
基金
以色列科学基金会; 美国国家卫生研究院;
关键词
Extracellular matrix; Heparan sulfate; Heparanase; Tumor microenvironment; Inflammation; Atherosclerosis; Diabetes; MAMMALIAN HEPARANASE; FACTOR EXPRESSION; CLONING; SULFATE; ENZYME; ANGIOGENESIS; PURIFICATION; METASTASIS; ACTIVATION;
D O I
10.1016/j.matbio.2013.03.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:220 / 222
页数:3
相关论文
共 36 条
[1]   Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment [J].
Abboud-Jarrous, Ghada ;
Atzmon, Ruth ;
Peretz, Tamar ;
Palermo, Carmela ;
Gadea, Bedrick B. ;
Joyce, Johanna A. ;
Vlodavsky, Israel .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (26) :18167-18176
[2]   Heparanase Regulates Thrombosis in Vascular Injury and Stent-Induced Flow Disturbance [J].
Baker, Aaron B. ;
Gibson, William J. ;
Kolachalama, Vijaya B. ;
Golomb, Mordechai ;
Indolfi, Laura ;
Spruell, Christopher ;
Zcharia, Eyal ;
Vlodavsky, Israel ;
Edelman, Elazer R. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (17) :1551-1560
[3]   Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression [J].
Blich, Miry ;
Golan, Amnon ;
Arvatz, Gil ;
Sebbag, Anat ;
Shafat, Itay ;
Sabo, Edmond ;
Cohen-Kaplan, Victoria ;
Petcherski, Sirouch ;
Avniel-Polak, Shani ;
Eitan, Amnon ;
Hammerman, Haim ;
Aronson, Doron ;
Axelman, Elena ;
Ilan, Neta ;
Nussbaum, Gabriel ;
Vlodavsky, Israel .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (02) :E56-+
[4]   Mutations in HPSE2 Cause Urofacial Syndrome (vol 86, pg 963, 2010) [J].
Daly, Sarah B. ;
Urquhart, Jill E. ;
Hilton, Emma ;
McKenzie, Edward A. ;
Kammerer, Richard A. ;
Lewis, Malcolm ;
Kerr, Bronwyn ;
Stuart, Helen ;
Donnai, Dian ;
Long, David A. ;
Burgu, Berk ;
Aydogdu, Ozgu ;
Derbent, Murat ;
Garcia-Minaur, Sixto ;
Reardon, Willie ;
Gener, Blanca ;
Shalev, Stavit ;
Smith, Rupert ;
Woolf, Adrian S. ;
Black, Graeme C. ;
Newman, William G. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2010, 87 (02) :309-309
[5]   PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models [J].
Dredge, K. ;
Hammond, E. ;
Handley, P. ;
Gonda, T. J. ;
Smith, M. T. ;
Vincent, C. ;
Brandt, R. ;
Ferro, V. ;
Bytheway, I. .
BRITISH JOURNAL OF CANCER, 2011, 104 (04) :635-642
[6]   The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation [J].
Ferro, V ;
Hammond, E ;
Fairweather, JK .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2004, 4 (06) :693-702
[7]   Human platelet heparanase: purification, characterization and catalytic activity [J].
Freeman, C ;
Parish, CR .
BIOCHEMICAL JOURNAL, 1998, 330 :1341-1350
[8]   Heparanase: busy at the cell surface [J].
Fux, Liat ;
Ilan, Neta ;
Sanderson, Ralph D. ;
Vlodavsky, Israel .
TRENDS IN BIOCHEMICAL SCIENCES, 2009, 34 (10) :511-519
[9]   Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice [J].
Gil, Natali ;
Goldberg, Rachel ;
Neuman, Tzahi ;
Garsen, Marjolein ;
Zcharia, Eyal ;
Rubinstein, Ariel M. ;
van Kuppevelt, Toin ;
Meirovitz, Amichay ;
Pisano, Claudio ;
Li, Jin-Ping ;
van der Vlag, Johan ;
Vlodavsky, Israel ;
Elkin, Michael .
DIABETES, 2012, 61 (01) :208-216
[10]   Heparanase induces endothelial cell migration via protein kinase B/Akt activation [J].
Gingis-Velitski, S ;
Zetser, A ;
Flugelman, MY ;
Vlodavsky, I ;
Ilan, N .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (22) :23536-23541