Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming

被引：14

作者：

Dey, Dilip ^{[1
]}

Evans, Gregory R. D. ^{[1
]}

机构：

[1] Univ Calif Irvine, Aesthet & Plast Surg Inst, Orange, CA 92868 USA

来源：

STEM CELLS INTERNATIONAL | 2011年 / 2011卷

关键词：

HUMAN ADIPOSE-TISSUE; IN-VITRO; HUMAN FIBROBLASTS; STROMAL CELLS; DIFFERENTIATION; INDUCTION; DERIVATION; FUSION; MURINE; OCT4;

D O I：

10.4061/2011/619583

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration, and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or repair of damaged tissue. The pluripotent stem cells can be derived from inner cell mass of blastocyst but its application is limited due to ethical concerns. The recent discovery of iPS with defined reprogramming factors has initiated a flurry of works on stem cell in various laboratories. The pluripotent cells can be derived from various differentiated adult cells as well as from adult stem cells by nuclear reprogramming, somatic cell nuclear transfer and so forth. In this review article, different aspects of nuclear reprogramming are discussed.

引用

页数：11

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