Hemodynamic Analysis of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: A Numerical Study of Patient-Specific Models

被引：0

作者：

Wang, Liping ^{[1
]}

Zhang, Mingjie ^{[1
]}

Chen, Xi ^{[1
]}

Hong, Haifa ^{[1
]}

Liu, Jinlong ^{[1
,2
,3
]}

Xu, Zhuoming ^{[1
]}

Hu, Liwei ^{[3
,4
]}

Zhong, Yumin ^{[3
,4
]}

Jin, Qichen ^{[5
]}

Chen, Lijun ^{[5
]}

Zhang, Yuqi ^{[5
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Dept Cardiothorac Surg, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Inst Pediat Translat Med, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Shanghai Engn Res Ctr Virtual Real Struct Heart D, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Dept Radiol, Shanghai, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Dept Pediat Cardiol, Shanghai, Peoples R China

来源：

2018 11TH INTERNATIONAL CONGRESS ON IMAGE AND SIGNAL PROCESSING, BIOMEDICAL ENGINEERING AND INFORMATICS (CISP-BMEI 2018) | 2018年

关键词：

pulmonary hypertension; computational fluid dynamics; hemodynamics; congenital heart disease; WALL SHEAR-STRESS; ENDOTHELIAL-CELLS; CHILDREN;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

pulmonary arterial hypertension (PAH) is a complication of congenital heart disease (CHD). In clinic, Right heart catheterization (RHC) can obtain the pressure of pulmonary arteries and transthoracic echocardiography (TTE) can acquire the velocity of pulmonary blood flow. However, neither RHC nor TTE can provide quantitative hemodynamics. Here, we use computational fluid dynamics (CFD) to study the hemodynamics of pulmonary arterial of patients with PAH associated with CHD. Compared with the normal pulmonary blood flow, the local hemodynamics, especially wall shear stress (WSS), energy loss (EL) and streamlines, displayed obvious differences in the patients with PAH-CHD. Lower WSS, higher EL and rotating flow were generated in the pulmonary artery with PAH-CHD. These results may have a close association with endothelial dysfunction and accelerate the progression of PH.

引用

页数：5

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