Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients

被引：3

作者：

Rosado-de-Castro, Paulo Henrique ^{[1
]}

Schmidt, Felipe da Rocha ^{[2
]}

Battistella, Valeria ^{[2
]}

Lopes de Souza, Sergio Augusto ^{[1
]}

Gutfilen, Bianca ^{[1
]}

dos Santos Goldenberg, Regina Coeli ^{[3
]}

Kasai-Brunswick, Tais Hanae ^{[3
]}

Vairo, Leandro ^{[3
]}

Silva, Rafaella Monteiro ^{[2
]}

Wajnberg, Eduardo ^{[1
]}

Alvarenga Americano do Brasil, Pedro Emmanuel ^{[4
]}

Gasparetto, Emerson Leandro ^{[1
]}

Maiolino, Angelo ^{[5
]}

Alves-Leon, Soniza Vieira ^{[2
]}

Andre, Charles ^{[2
]}

Mendez-Otero, Rosalia

de Freitas, Gabriel Rodriguez ^{[3
,4
]}

Barbosa da Fonseca, Lea Mirian ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Ilha Fundao, Sch Med, Dept Radiol, BR-21941913 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Neurol Serv, BR-21941913 Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, Ilha Fundao, Inst Biofis Carlos Chagas Filho, CCS, BR-21941590 Rio De Janeiro, Brazil

[4] DOr Inst Res & Educ, Rio De Janeiro, Brazil

[5] Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Hematol Serv, BR-21941913 Rio De Janeiro, Brazil

来源：

REGENERATIVE MEDICINE | 2013年 / 8卷 / 02期

关键词：

Tc-99m; bone marrow mononuclear cells; cell transplatation; cerebral infarct; scinitigraphy; MESENCHYMAL STEM-CELLS; ISCHEMIC-STROKE; STROMAL CELLS; THERAPEUTIC BENEFIT; CEREBRAL-ISCHEMIA; NEUROTRANSPLANTATION; SEIZURES; DELIVERY; SAFETY; INJURY;

D O I：

10.2217/RME.13.2

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Aims: To assess the biodistribution of bone marrow mononuclear cells (BMMNC) delivered by different routes in patients with subacute middle cerebral artery ischemic stroke. Patients & methods: This was a nonrandomized, open-label Phase I clinical trial. After bone marrow harvesting, BMMNCs were labeled with technetium-99m and intra-arterially or intravenously delivered together with the unlabeled cells. Scintigraphies were carried out at 2 and 24 h after cell transplantation. Clinical follow-up was continued for 6 months. Results: Twelve patients were included, between 19 and 89 days after stroke, and received 1-5 x 10(8) BMMNCs. The intra-arterial group had greater radioactive counts in the liver and spleen and lower counts in the lungs at 2 and 24 h, while in the brain they were low and similar for both routes. Conclusion: BMMNC labeling with technetium-99m allowed imaging for up to 24 h after intra-arterial or intravenous injection in stroke patients.

引用

页码：145 / 155

页数：11

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