PGFM response to exogenous oxytocin and determination of the half-life of oxytocin in nonpregnant mares

被引：31
作者：
Paccamonti, DL
Pycock, JF
Taverne, MAM
Bevers, M
van der Weijden, GC
Gutjahr, S
Schams, D
Blouin, D
机构：
[1] Univ Utrecht, Dept Herd Hlth & Reprod, NL-3584 CL Utrecht, Netherlands
[2] Univ Leipzig, Dept Vet Obstet & Gynaecol, D-04103 Leipzig, Germany
[3] Tech Univ Munich, Dept Physiol, D-8050 Freising, Germany
[4] Louisiana State Univ, Dept Expt Stat, Baton Rouge, LA 70803 USA
来源：
EQUINE VETERINARY JOURNAL | 1999年 / 31卷 / 04期
关键词：
horse; oxytocin; prostaglandin; mare; uterus;
D O I：
10.1111/j.2042-3306.1999.tb03818.x
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
We investigated the half-life of oxytocin in reproductively normal mares and the prostaglandin response after oxytocin administrations. Mares were given oxytocin, 10 or 25 iu, i.v., on the day of, or 2 days after, ovulation, and frequent jugular blood samples were collected for analysis of oxytocin and Prostaglandin F metabolite (PGFM) by RIA, Neither dose of oxytocin nor day of treatment affected the half-life of the exogenous oxytocin, which was determined to be 6.8 min. A significant increase in PGFM was observed within 6 min of oxytocin administration and peak values were observed within 10 min. PGFM response after oxytocin administration on the day of ovulation appeared elevated compared to the response 2 days after ovulation.
引用
收藏
页码：285 / 288
页数：4
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