Developments in the integration and application of terahertz spectroscopy with microfluidics

被引：40

作者：

Alfihed, Salman ^{[1
,2
]}

Holzman, Jonathan F. ^{[1
]}

Foulds, Ian G. ^{[1
]}

机构：

[1] Univ British Columbia, Sch Engn, Kelowna, BC V1V 1V7, Canada

[2] King Abdulaziz City Sci & Technol, Mat Sci Res Inst, Riyadh 11442, Saudi Arabia

来源：

BIOSENSORS & BIOELECTRONICS | 2020年 / 165卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Terahertz time-domain spectroscopy; Microfluidic platforms; Biosensors; TIME-DOMAIN SPECTROSCOPY; FAR-INFRARED ABSORPTION; VIBRATIONAL-MODES; DNA; TRANSMISSION; PDMS;

D O I：

10.1016/j.bios.2020.112393

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

This work presents an overview of terahertz (THz) spectroscopy with a focus on its implementation within microfluidic platforms. Such platforms are of great interest because they can enable label-free and reagent-free sensing. However, they must be implemented with thought towards the incorporated materials and structures as they can greatly impact the bandwidth, frequency resolution, signal-to-noise ratio, and dynamic range of the measurements. This review explores such relationships with insight given on the design and material considerations for the effective integration of THz spectroscopy in microfluidic platforms. The review also describes recent work on the application of THz spectroscopy to biomaterial analyses on increasing scales, targeting DNA, proteins, cells, and tissues.

引用

页数：11

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