Pathogenesis of Langerhans Cell Histiocytosis

被引:94
作者
Badalian-Very, Gayane [1 ,2 ]
Vergilio, Jo-Anne [3 ]
Fleming, Mark [4 ,5 ]
Rollins, Barrett J. [1 ,2 ]
机构
[1] Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp, Boston, MA 02215 USA
[3] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[4] Childrens Hosp, Dept Pathol, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 8 | 2013年 / 8卷
关键词
dendritic cells; BRAF; CHEMOKINE RECEPTOR EXPRESSION; LA MICROSCOPIE ELECTRONIQUE; DENDRITIC CELLS; EOSINOPHILIC GRANULOMA; SOLITARY GRANULOMA; ADHESION MOLECULES; MEMBRANOUS BONES; BRAF MUTATIONS; X CELLS; P53;
D O I
10.1146/annurev-pathol-020712-163959
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Langerhans cell histiocytosis (LCH) combines in one nosological category a group of diseases that have widely disparate clinical manifestations but are all characterized by accumulation of proliferating cells with surface markers and ultrastructural features similar to cutaneous Langerhans cells (LCs). Despite this unified nosology, important questions about LCH remain unanswered. First, despite having phenotypic features of LCs, LCH cell gene-expression patterns differ from those in LCs. Although this observation suggests that LCH may arise from an earlier precursor, it is not necessarily inconsistent with the hypothesis that LCs are the cell of origin for LCH. Second, LCH's prominent inflammatory component and occasional benign clinical course suggest that LCH may not be a neoplasm. However, the demonstration that LCH cells are clonal, along with the recent discovery of activating BRAF mutations in LCH cells, strongly suggests that LCH is a neoplastic disease. These new observations point the way to rationally targeted therapies.
引用
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页码:1 / 20
页数:20
相关论文
共 126 条
[71]  
LICHTENSTEIN L, 1953, AMA ARCH PATHOL, V56, P84
[72]  
Lichtenstein L, 1940, AM J PATHOL, V16, P595
[73]   Polyclonality of BRAF Mutations in Acquired Melanocytic Nevi [J].
Lin, Jingrong ;
Takata, Minoru ;
Murata, Hiroshi ;
Goto, Yasufumi ;
Kido, Kenji ;
Ferrone, Soldano ;
Saida, Toshiaki .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2009, 101 (20) :1423-1427
[74]   Origin of dendritic cells in peripheral lymphoid organs of mice [J].
Liu, Kang ;
Waskow, Claudia ;
Liu, Xiangtao ;
Yao, Kaihui ;
Hoh, Josephine ;
Nussenzweig, Michel .
NATURE IMMUNOLOGY, 2007, 8 (06) :578-583
[75]   In Vivo Analysis of Dendritic Cell Development and Homeostasis [J].
Liu, Kang ;
Victora, Gabriel D. ;
Schwickert, Tanja A. ;
Guermonprez, Pierre ;
Meredith, Matthew M. ;
Yao, Kaihui ;
Chu, Fei-Fan ;
Randolph, Gwendalyn J. ;
Rudensky, Alexander Y. ;
Nussenzweig, Michel .
SCIENCE, 2009, 324 (5925) :392-397
[76]   Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples [J].
MacConaill, Laura E. ;
Campbell, Catarina D. ;
Kehoe, Sarah M. ;
Bass, Adam J. ;
Hatton, Charles ;
Niu, Lili ;
Davis, Matt ;
Yao, Keluo ;
Hanna, Megan ;
Mondal, Chandrani ;
Luongo, Lauren ;
Emery, Caroline M. ;
Baker, Alissa C. ;
Philips, Juliet ;
Goff, Deborah J. ;
Fiorentino, Michelangelo ;
Rubin, Mark A. ;
Polyak, Kornelia ;
Chan, Jennifer ;
Wang, Yuexiang ;
Fletcher, Jonathan A. ;
Santagata, Sandro ;
Corso, Gianni ;
Roviello, Franco ;
Shivdasani, Ramesh ;
Kieran, Mark W. ;
Ligon, Keith L. ;
Stiles, Charles D. ;
Hahn, William C. ;
Meyerson, Matthew L. ;
Garraway, Levi A. .
PLOS ONE, 2009, 4 (11)
[77]   Pathology diseases of bone [J].
Mallory, TB .
NEW ENGLAND JOURNAL OF MEDICINE, 1942, 227 :955-960
[78]   Flk2+ myeloid progenitors are the main source of Langerhans cells [J].
Mende, I ;
Karsunky, H ;
Weissman, IL ;
Engleman, EG ;
Merad, M .
BLOOD, 2006, 107 (04) :1383-1390
[79]   Langerhans cells renew in the skin throughout life under steady-state conditions [J].
Miriam Merad ;
Markus G. Manz ;
Holger Karsunky ;
Amy Wagers ;
Wendy Peters ;
Israel Charo ;
Irving L. Weissman ;
Jason G. Cyster ;
Edgar G. Engleman .
Nature Immunology, 2002, 3 (12) :1135-1141
[80]   BRAFE600-associated senescence-like cell cycle arrest of human naevi [J].
Michaloglou, C ;
Vredeveld, LCW ;
Soengas, MS ;
Denoyelle, C ;
Kuilman, T ;
van der Horst, CMAM ;
Majoor, DM ;
Shay, JW ;
Mooi, WJ ;
Peeper, DS .
NATURE, 2005, 436 (7051) :720-724