Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials

被引：141
作者：
Wang, Li-Tzu [1 ,2 ]
Ting, Chiao-Hsuan [1 ]
Yen, Men-Luh [3 ,4 ]
Liu, Ko-Jiunn [5 ]
Sytwu, Huey-Kang [2 ,6 ]
Wu, Kenneth K. [1 ,7 ]
Yen, B. Linju [1 ]
机构：
[1] Natl Hlth Res Inst, Inst Cellular & Syst Med, Regenerat Med Res Grp, 35 Keyan Rd, Zhunan 35053, Taiwan
[2] NDMC, Grad Inst Life Sci, Taipei, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Ob Gyn, Taipei, Taiwan
[4] Natl Taiwan Univ, Coll Med, Taipei, Taiwan
[5] NHRI, Natl Inst Canc Res, Tainan, Taiwan
[6] NDMC, Grad Inst Microbiol & Immunol, Taipei, Taiwan
[7] China Med Coll, Grad Inst Basic Med Sci, Taichung, Taiwan
来源：
JOURNAL OF BIOMEDICAL SCIENCE | 2016年 / 23卷
关键词：
Mesenchymal stem cells; Human; Immunomodulation; Inflammation; Clinical trials; Autoimmune disease; Organ transplantation and rejection; Stem cell therapy; VERSUS-HOST-DISEASE; ACUTE LUNG INJURY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ALLERGIC AIRWAY INFLAMMATION; DSS-INDUCED COLITIS; STROMAL CELLS; MOUSE MODEL; CROHNS-DISEASE; IN-VITRO; LYMPHOCYTE-PROLIFERATION;
D O I：
10.1186/s12929-016-0289-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. This has opened up the use of these versatile cells for application as 3rd party/allogeneic use in cell replacement/tissue regeneration, as well as for immune-and inflammation-mediated disease entities. Most surprisingly, use of MSCs for in immune-/inflammation-mediated diseases appears to yield more efficacy than for regenerative medicine, since engraftment of the exogenous cell does not appear necessary. In this review, we focus on this non-traditional clinical use of a tissue-specific stem cell, and highlight important findings and trends in this exciting area of stem cell therapy.
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页码：1 / 13
页数：13
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